Within the Western Psychiatric Institute and Clinic (WPIC) Department of Psychiatry, our Mood Disorders Treatment and Research Program (MDTRP) has had long-standing and extensive experience in a wide variety of mood disorders research that includes:

1. Multi-center collaborative and single-site clinical treatment trials for various types of depressive and bipolar disorders;
2. Psychopharmacology treatment studies (investigational and FDA-approved drugs) for major depression and bipolar disorder;
3. Psychotherapy treatment studies for depressive disorders;
4. Neurostimulation therapies for treatment resistant depression;
5. Combining neuroimaging and treatment studies of major depression.

Mood Disorder Programs:

1. Major depression:
   1. Cognitive behavioral therapy (CBT) for relapse prevention of depression (NIMH)
   2. Combining medications to enhance depression outcomes (Depression Trials Network)
   3. Improving depression outcome by adding CBT for insomnia to antidepressants (NIMH)
   4. Physiological and neuroimaging assessment of depression (NIMH)
   5. Attention control intervention for depression (NIMH)
2. Treatment resistant depression (TRD):
   1. Vagus nerve stimulation (VNS) for TRD (Cyberonics)
   2. Cortical brain stimulation for TRD (Northstar Neuroscience)
   3. Deep brain stimulation for TRD (Medtronic)
   4. Electroconvulsive therapy (ECT) for depression (clinical service)
3. Bipolar disorder:
   1. Lithium treatment for bipolar disorder (Bipolar Trials Network

Anxiety disorders

1. Obsessive-compulsive disorder (OCD):
   1. Pharmacotherapy (clinical service);
   2. Intensive behavioral therapy program (clinical service);
   3. Neurosurgical interventions (capsulotomy; deep brain stimulation)
2. Post-traumatic stress disorder (PTSD):
   1. Neuroimaging study of pharmacological and behavioral therapies for PTSD (proposal pending)
3. Treatment resistant anxiety disorders:
   1. Vagus nerve stimulation for treatment resistant anxiety disorders (OCD, PTSD, panic) (previous pilot project)