Deep Brain Stimulation Q&A
What are the cosmetic considerations with DBS surgery?
Complete shaving of the head is not necessary for surgery. However, patches of hair on top of the head and behind the ear are shaved immediately before surgery when the patient is sedated. Many patients elect to get a short haircut after surgery (must be at least 2 weeks afterwards) so that the hair grows in evenly.
There are generally 3 incisions made on each side for DBS surgery: a 5 cm (2 inch) incision on top of the head, a 2.5 cm (1 inch) incision behind the ear, and a 6 cm (2.5 inches) incision in the chest just under the clavicle. For patients with receding hairlines, a slight scar from an incision will be visible on top of the head, but is not especially prominent. The cap used to anchor the DBS electrode (under the scalp) forms a slight bump, which again may be visible in the case of a receding hairline.
There is often puffiness around the eyes for a few days after surgery, but this goes away rapidly. The local anesthetic given when the frame is placed can cause swelling in the face, around the eyes, usually at its peak of one to three days after surgery.
All parts of the device are internal (under the skin), so there are no wires sticking out. In a thin person, the connecting wire running down the neck may be visible as a slight bulge when the head is turned all the way to the opposite side. The incision for the pulse generator in the chest is closed with particular attention to minimize scar formation; this incision would be visible with the shirt off, or in a swimsuit, or in a low-cut evening gown. In thin persons, the pulse generator itself forms a bulge under the skin in the pectoral area that may be apparent if the area is uncovered, but is not visible through clothing.
Why must patients be awake for part of DBS surgery?
Using the standard, microelectrode guided technique for DBS surgery, brain mapping is performed using microelectrodes. The brain mapping procedure is much harder to do if the patient is under a general anesthetic or strong sedative. In addition, the procedure is safer if the patient's neurological function (speech and voluntary movement) can be checked periodically during the procedure, which is only possible in an awake patient. For patients undergoing surgery in our investigational interventional MRI protocol, general anesthesia is used for the whole procedure, as the MR images take the place of electrical mapping and monitoring of neurological function.
Would both sides of the brain be done at once, or only one side?
DBS on one side of the brain mainly affects symptoms on the opposite side of the body. Most patients have symptoms on both sides of the body and thus require both sides of the brain to be implanted for maximal benefit. In the first several years of our DBS program, most implant surgeries were "staged," that is each side done in a separate surgery separated by several months. As this surgery has become more rapid and routine, we are now offering "simultaneous bilateral" procedures, or implantation of both leads in a single surgery, to many patients. The brain side opposite the most affected body side is implanted first. Then, if the patient and anesthesiologist agree to proceed, the second side is then implanted. For elderly patients, or patients concerned about a longer operation, it may be best to stage the procedures several months apart.
What are the benefits of DBS surgery?
The major benefit of DBS surgery for PD is that it makes movement in the off-medication state more like the movement in the on-medication state. In addition, it reduces levodopa-induced dyskinesias, either by a direct suppressive effect or indirectly by allowing some reduction in medication dose. Thus, the procedure is most beneficial for Parkinson's patients who cycle between states of immobility ("off" state) and states of better mobility ("on" state). DBS smoothes out these fluctuations so that there is better function during more of the day. Any symptom that can improve with levodopa (slowness, stiffness, tremor, gait disorder) can also improve with DBS. Symptoms that do not respond at all to levodopa usually do not improve significantly with DBS. Following DBS, there may be a reduction, but not elimination, of anti-Parkinsonian medications. At present, we believe that DBS only suppresses symptoms and does not alter the underlying progression of Parkinson's disease.
What are the risks of DBS surgery?
The most serious potential risk of the surgical procedures is bleeding in the brain, producing a stroke. This risk varies from patient to patient, depending on the overall medical condition, but the average risk is about 2%. If stroke occurs, it usually occurs during, or within a few hours of, surgery. The effects of stroke can range from mild weakness that recovers in a few weeks or months to severe, permanent weakness, intellectual impairment, or death. The second most serious risk is infection, which occurs in about 4% of patients. If an infection occurs, it is usually not life threatening, but it may require removal of the entire DBS system. In most cases, a new DBS system can be re-implanted when the infection is healed. Finally, hardware may break or erode through the skin with normal usage, requiring it to be replaced.
In the first few days after surgery, it is normal to have some temporary swelling of the brain tissue around the electrode. This may produce no symptoms, but it can produce mild disorientation, sleepiness, or personality change that lasts for up to 1-2 weeks.
What makes a patient a good candidate for DBS for Parkinson's disease?
In determining whether a patient is a good candidate for surgery, we look for the following:
- Intact intellectual function and memory. Dementia (significantly impaired memory or thinking) is a major contraindication to surgery, since such patients have great difficulty tolerating the surgery, may have further loss of intellectual function due to the surgery, deal poorly with the complexity of DBS therapy, and realize little overall functional benefit.
- History of significant benefit from taking levodopa (Sinemet). Good mobility, with the ability to walk, in the best "on-medication" state is important for a good outcome. In general, surgery makes the "off" medication state more like the "on" state but rarely does better than the best "on" state, so a patient with poor function in best "on" (for example, unable to walk at any time) is a poor surgical candidate
- Certainty of diagnosis. A number of neurological illnesses can mimic the symptoms of Parkinson's disease but do not respond significantly to levodopa. Such illnesses are often called "atypical parkinsonism" or "Parkinson's plus syndromes." These illnesses are different from classic Parkinson's disease, and they do not respond to DBS surgery. If there is a strong possibility that the patient has atypical parkinsonism rather than classic Parkinson's disease, surgery should not be performed.
- Lack of other untreated or inadequately treated illnesses. Serious cardiac disease, uncontrolled hypertension, or any major other chronic systemic illness increases the risk and decreases the benefit of surgery.
- Realistic expectations. People who expect a sudden miracle are disappointed with the results, and they may have difficulty with the complexity of the therapy.
- Patient age. The benefits of DBS for PD decline with advancing age, and the risks go up. We rarely offer surgery to a person over 80 and would only consider it if they are in otherwise excellent health, are cognitively intact, and have good function in the on state. For patients over 75, the benefits are likely to be modest.
- MRI of the brain should be free of severe vascular disease, extensive atrophy, or signs of atypical parkinsonism.
- Degree of disability. DBS is a poor procedure to rescue someone with end stage Parkinson's disease who is wheelchair bound or in a nursing home, although these are the most desperate patients. It is an excellent procedure for Parkinson's patients who are still employed but may be just at the point where disability would stop them from working.
- Ability to remain calm and cooperative during an awake neurosurgical procedure lasting 2-3 hours per brain side.
Where is the surgery performed?
For patients referred to the Movement Disorders Surgery Program at UCSF, surgery is performed at the UCSF Medical Center (Moffitt Hospital) at 505 Parnassus Avenue. Our surgical team also performs DBS surgery for patients in the Veterans Health Care system, at the San Francisco Veterans Affairs Medical Center at 4150 Clement Street.
What are the results and complications of DBS at UCSF?
Since beginning our DBS program in 1998, we have performed over 1000 implants for movement disorders. Seven hundred of these have been STN or GPi implants for Parkinson's disease. A subset of our patients has had formal neurological evaluations on and off of medications, with the stimulators on and off. For bilateral DBS, the evaluations showed a 45-70% improvement in the scores on standard rating scales, off of medication, as a result of DBS. This is similar to the results from other major centers and represents a major improvement in mobility. In our series, the risk of stroke is 1.6%, the risk of severe stroke with death or permanent major disability is 0.5%, and the risk of device infection that requires further surgery for device removal is 4%.
What clinical trials are available at UCSF for Parkinson’s disease, and what are the advantages of participating in them?
We have recently completed enrollment of a 316-patient, 9 single-center trial of GPi versus STN DBS for Parkinson's disease, and we continue to collect data on those patients. We have completed a phase II, 8-center trial of gene transfer, introducing a gene encoding a growth factor, for Parkinson’s disease. We have ongoing trials to study new DBS devices, new technical approaches to DBS including use of interventional MRI, and brain physiology in movement disorders.
What determines the choice of STN versus GPi as the target?
In the future, the target choice will be made based upon what will give the best result for an individual patient's symptoms. At this time, data show that both STN and GPi DBS are effective for most symptoms, and it is not clear if one is a better target. For patients who were enrolled in our formal clinical trial of DBS for PD, the choice of STN or GPi is determined by randomization. If not enrolled in the trial, the target choice is made largely by preference of the patient and referring neurologist.
What tests are needed prior to surgery?
Patients should have a brain imaging study (MRI or CT) to determine if there are problems in the brain that would pose excessive risk for surgery, unless one has been done within 1 year. Most patients should have a formal neurological exam in the off-medication condition, following by re-assessment after a test dose of medication, by one of our neurologists or by the referring neurologist. For any patient with a question of cognitive dysfunction, we request formal neuropsychological evaluation. All patients must have a blood test (mainly for blood clotting ability) and consultation with the anesthesiologists in the week prior to surgery. For patients interested in the interventional MRI implantation protocol, the patients must have an “on medication, off medication” test once before surgery and then again approximately 6 months after surgery.
How should the patient prepare for surgery?
For 10 days prior to surgery, patients must not take aspirin, any aspirin containing drugs, related drugs such as ibuprofen (Advil, Motrin) or naproxen (Naprosyn), or Vitamin E. These drugs can increase the risk of bleeding. The evening before surgery, patients should wash their head, neck, and chest with hibiclens (or other soap containing chlorhexidine) in the shower. The morning of surgery, the patient should not take their antiparkinsonian medications. However, the patient should take any medications they normally take for other problems, such as high blood pressure. Patients should inform the surgeon if they develop a cold, cough, or any type of infection in the days prior to the surgery. Patients should be well hydrated (drink a lot of non-alcoholic, non-caffeinated drinks) prior to surgery.
What type of follow-up is needed after surgery? Who will program the DBS unit?
Patients normally leave the hospital two days after surgery. We ask patients to return to our clinic 1 week later for suture removal and check of the incisions by our DBS nurse, and approximately 4 weeks later to see the surgeon and neurologist in the Movement Disorders Surgery Clinic. The initial programming is done at UCSF usually at the one-week postoperative visit. Some patients have temporary disorientation or sleepiness for a few days after surgery due to temporary brain swelling, and if this occurs programming is deferred until the mental state completely returns to baseline. For subsequent programming needs after the initial stimulator activation, the patient is welcome to continue in our Movement Disorders Clinic. For patients who have neurologists outside of UCSF who are comfortable with programming, it is often most convenient to return to their regular neurologist. We are happy to advise referring neurologists regarding programming strategies, and we have close working relationships with our major referring doctors around the Bay Area, West Coast and Hawaii.
In the first month or two following DBS implantation, some patients may develop an infection of the device or of the skin over the device. This would present as drainage, increasing redness, increasing swelling, or increasing pain starting a few days to a few weeks post-surgery. It is very important to let our office know IMMEDIATELY if such signs are noted, since early wound care may be effective at salvaging the device. If such symptoms are ignored for even a few days, however, the patient will usually have to have all of the hardware removed.
Patients will typically require replacement of the pulse generator after 3-4 years, depending on the exact settings of the device (for non-rechargable neurostimulators). This is an outpatient procedure that takes about 30 minutes. Since 2009, a rechargeable pulse generator has been available, which lasts much longer than the other pulse generators (about 9 years).
How long does it take before the full benefit of DBS is apparent?
For reasons that are not fully understood, the improvement in parkinsonisan symptoms my take a few hours or days to reach its maximal level following a programming change. Some problems may respond more quickly than others. In addition, to realize the full benefit of DBS, medication changes and multiple programming sessions may be needed. Thus it is usually a few months after surgery before the final degree of benefit is actually realized.
Can patients control the DBS device themselves?
Following surgery, the patient is given the Medtronic Access Review unit, a hand-held battery-operated unit that can be used to determine if the device is on or off, to turn it on or off, and to check battery life. In addition, the newer pulse generator (the Medtronic Kinetra) allows some patient control over the stimulation level. Normally, in DBS for Parkinson's disease, the device is left on all the time.
Are there any restrictions on a person's activity after a DBS system is implanted?
For at least 7 days after surgery, the patient should refrain from flying in commercial aircraft. For one week after surgery, the incisions should be kept dry, so for showering in the first week incisions must be covered with an occlusive dressing. Tight clothing or tightly fitting hats should be avoided in the two weeks after surgery. After the incisions are completely healed (2-3 weeks), the patient may return to all normal activities, including exercise. Patients are advised not to drive for at least one week following surgery. For the first 2 weeks after surgery, the patient should not lift more than 10 pounds. Normal physical activities will not harm the device. Security devices (such as those in airports or stores) will not harm the device or the patient, although in rare cases they may activate the on-off switch, thus turning off a DBS system that had been on. The loss of benefit to the patient may take minutes or hours to be apparent. When traveling extensively away from home, patients should carry their Medtronic Access Review unit so that they can easily re-activate the DBS system if it is de-activated by a security device.
Can I have an MRI scan after DBS?
After DBS implantation, patients should avoid most types of MRI exams, as the exam may produce heating of the brain electrode. At UCSF, we have developed a specialized, low-energy protocol for brain MRI, allowing us to perform postoperative brain MRI safely. However, we do not recommend any other forms of MRI (such as spine or chest MRI), because safe conditions for performing these have not been worked out.
Is DBS surgery covered by health insurance?
Medicare and almost all private insurers in California now cover DBS for Parkinson's disease. Insurance approval is sought prior to hospital admission.