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Department Faculty |
Robert J. Ferrante, PhD, MS |
Professor of Neurological Surgery Specialized Areas of Interest: Neuropathology and mechanisms of neurodegeneration in adult-onset neurological diseases, with special interest in Huntington's Disease and amyotrophic lateral sclerosis; drug development and translational therapeutic strategies, biomarker discovery, and human clinical trials. Biography: Robert J. Ferrante, PhD, MS, joined the Department of Neurological Surgery in July of 2011. Prior to coming to Pittsburgh, Dr. Ferrante spent over 20 years at Harvard Medical School and the Massachusetts General Hospital in Boston in anatomical and experimental neuropathology under the tutelage of Drs. Edward P. Richardson, Jr. and Joseph B. Martin, publishing a number of seminal findings associated with the etiology and progression of neurological conditions, with one series of studies leading to the novel discovery of selective neuronal vulnerability and sparing in Huntington’s disease. This work initiated and strengthened current hypotheses of cell death. In 1993 he accepted a position at the Boston University School of Medicine and the Boston Veterans Administration System, and served as a professor of Neurology, Laboratory Medicine and Pathology, Psychiatry, and Behavioral Neuroscience, as well as the director of the Experimental Neuropathology and Translational Therapeutics Laboratory. Dr. Ferrante is a visiting professor in Neuroscience at Amherst College. He received both his doctorate and bachelor degree from Boston University. Dr. Ferrante has a wide-range of knowledge about the neuropathology and mechanisms of neurodegeneration in adult-onset neurological diseases, with more than 30 years experience in clinical and experimental neurology. He is considered an expert in the application of experimental models of disease and in bench to bedside translational studies. Over the past 20 years, Dr. Ferrante has developed an international reputation as having one of the premier translational programs for understanding pathophysiological mechanisms of neurological disease and for developing and characterizing therapeutic strategies for these conditions. His work has set the standard for others in the field. His laboratory has been a driving force in completing pre-clinical drug trials in mouse models of neurological disease and has acted as a conduit of therapeutic agents for direct translation to human clinical trials in Huntington’s disease and amyotrophic lateral sclerosis patients. This work has provided the basis for human trials using coenzyme Q10, creatine, cysteamine, sodium phenylbutyrate, amongst others. He has directed patient trails in the Veterans Administration and remains on multiple steering committees in advancing human clinical trials. He has had continuous grant funding since 1988 and is the holder of multiple patents. A major goal of Dr. Ferrante’s current clinical research is to identify parallels in peripheral and central biomarker detection of disease and manifestations of neuronal dysfunction with translation to potential disease-modifying therapies that are being developed and evaluated in the clinical setting, especially in early stage disease. The goal is to create a data set of multiple markers that can be used with multivariate techniques to develop a unique biochemical signature relating to neurological diseases and to evaluate correlative biomarkers and biomarkers in response to therapy. Dr. Ferrante's work has garnered national and international recognition and he is regularly invited to lecture nationally and internationally. He sits on multiple boards and committees, and on grant review panels for the NIH and the VA, as well as disease-related foundations. Dr. Ferrante is section editor for Molecular Basis of Disease at Biochimica et Biophysica, and a regular referee for many other journals. He has received multiple honorary awards for his research and dedication to patients with neurological conditions. Dr. Ferrante's publications can be reviewed through the National Library of Medicine's publication database. Professional Organization Membership: Society for Neurosciences Editorial Service • Editorial Boards: Molecular Basis of Disease • Ad Hoc Reviewer: Journal of Neuroscience |
Dr. Ferrante
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