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Department Faculty

Robert M. Friedlander, MD

Chairman, Professor of Neurological Surgery
Endowed Chair of Neurological Surgery
Head of
Cerebrovascular Neurosurgery
Phone: (412) 647-6358
e-mail: dudekgl@upmc.edu

Also see Media Appearances below.

Specialized Areas of Interest

Aneurysms, vascular malformations, brain tumors, carotid disease, cerebrovascular disease, Chiari malformation, spinal cord tumors. Research focuses on mechanisms of apoptosis, Huntington’s disease, ALS, and stroke.

Biography

On June 1, 2010, Robert M. Friedlander, MD, became the fourth chair in the department’s history. Prior to joining the department, Dr. Friedlander was professor of neurosurgery at Harvard Medical School and vice-chairman of neurosurgery and associate director of cerebrovascular surgery at Brigham and Women’s Hospital in Boston.

As a sign of his prominence as a clinician and scientist, Dr. Friedlander, 44, is one of a very select group of authors to have been invited by the New England Journal of Medicine to write both a basic science review (mechanisms of neuronal cell death), as well as a clinical review (management of AVMs). Clinically, Dr. Friedlander focuses on the operative management of complex cerebrovascular disorders and brain tumors.

Dr. Friedlander’s major research interests lie in the study of the mechanistic pathways of the caspase apoptosis gene family. As co-director of Brigham and Women’s Neuroscience Research Center, his work includes the evaluation of treatment strategies for neurodegenerative diseases (Huntington’s and ALS), stroke, brain trauma, and spinal cord injury through the modulation of the caspase-family apoptotic pathways.

Dr. Friedlander’s research has received significant media attention including major work published in Nature, Science, and Nature Medicine.

His work has also been recognized through many academic awards, including the Neurosurgery Resident Award from the Congress of Neurological Surgeons, the Bayer Cerebrovascular Award from the Joint Section of Cerebrovascular Surgery, the International Charcot Prize for Motor Neuron Diseases, and the Award from the Academy of Neurological Surgeons. In 2006, he was elected as a member of the prestigious America Society for Clinical Investigation

Dr. Friedlander's publications can be reviewed through the National Library of Medicine's publication database.

Board Certifications

American Board of Neurological Surgery

Hospital Privileges

Children’s Hospital of Pittsburgh of UPMC
UPMC Mercy
UPMC Passavant
UPMC Presbyterian
UPMC Shadyside

Professional Organization Membership

American Association for the Advancement of Science
Congress of Neurological Surgeons.
American Association of Neurological Surgeons
Joint Section of Cerebrovascular Surgery
Society for Neuroscience
American Society for Clinical Investigation
Sociedad Venezolana de Neurocirugia (Honorary Member)
The American Academy of Neurological Surgeons
Society for Neurological Surgeons

Editorial Service

• Editorial Board:

Journal of Neuroscience
Neurosurgery

• Ad Hoc Reviewer:

Nature Medicine
Nature Genetics
Cell Death and Differentiation
Journal of Neuroscience
Nature Reviews Molecular Biology
Human Molecular Genetics
Nature
Trends in Neuroscience
Science
Nature Cell Biology
Experimental Neurology
Journal of Neurochemistry
Neuroscience Letters
Neuron
Proceedings of the National Academy of Sciences
New England Journal of Medicine
Neurosurgery
Annals of Neurology
EMBO
Neuropharmacology
Journal of Biological Chemistry
Nature Biotechnology
Letters in Drug Design and Discovery
Nature Neuroscience

Media Appearances

Melatonin Delays Onset, Reduces Deaths in Mouse Model of Huntington’s Disease
October 11, 2011
Science Daily

Rep. Giffords has surgery to repair skull
May 19, 2011
Washington Times (Associated Press)

Caspases—Guilty of Murder in First, and Now Second Degrees
March 12, 2011
Altzheimer Research Forum

UPMC Doctor Discusses Prognosis For Rep. Gabrielle Giffords
January 10, 2011
WTAE-TV (Pittsburgh) Action News

Blocking Apoptosis Delays ALS in Mice
October 15, 2010
Altzheimer Research Forum

The lasting impact of concussions
August 18, 2010
Yahoo! Sports

What caused the woman's headache and paralysis?
July 13, 2004
Boston Globe

Newsmaker: Dr. Robert Friedlander
June 17, 2010
Pittsburgh Tribune-Review

Antibiotic May Slow Gehrig's Disease
May 6, 2002
Associated Press

An Old Antibiotic Generates New Hopes
July 11, 2000
New York Times

Minocycline slows progress of Huntington's disease in mice
July 8, 2000
British Medical Journal

Antibiotic may help fight Huntington's
June 27, 2000
USA Today

Brain drug shows promise: Slows ALS, may treat other diseases
April 14, 2000
Boston Herald

Lou Gehrig's disease slowed in mice
April 14, 2000
Boston Globe (Associated Press)

Way To Delay Huntington's Disease Found
June 19, 1999
Harvard University Gazette

Scientists slow progress of Huntington's in mice
May 20, 1999
CNN.com

Hope in Brain-Disorder Fight/Tests yield Huntington's clues
May 20, 1999
Newsday

Approach may slow Huntington’s
May 19, 1999
MSNBC.com

Scientists slow progress of Huntington's in mice
May 19, 1999
ABC News

Study Targets Huntington's Key
May 19, 1999
CBS News

Friedlander

Dr. Friedlander

Neuroapoptosis Laboratory