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Brain Modulation Laboratory

The Brain Modulation Laboratory, directed by R. Mark Richardson, MD, PhD, studies human brain electrophysiology, imaging, histopathology and cognition in patients undergoing surgery for epilepsy and movement disorders. A primary focus of the lab is to understand the neurophysiological basis of different brain functions via invasive recording of brain activity in awake patients performing behavioral tasks. The goal of these studies is to improve our understanding of potential targets for therapeutic modulation. A related focus of the lab is the development of nonhuman primate models to test novel hypotheses related to the treatment of these disorders. In the past academic year, the lab’s research has been published in Journal of Neurophysiology, Human Brain Mapping, PNAS, and Brain.

Current projects include the following:

Basal Ganglia-Cortical Dynamics in Human Behavior
Intraoperatively, the Brain Modulation Lab collects task-based, simultaneously recorded cortical ECoG and subcortical MER/LFP data to study interactions between the cortex and basal ganglia that code for specific components of motor action. 

Cortical Effects of DBS Studied with Magnetoelcephalography 
The lab is one of the few research programs in the world using magnetoencephalography (MEG) to study the effects of deep brain stimulation (DBS) on cortical function. 

Brain Stimulation for Epilepsy
The Brain Modulation Lab is studying the effects of stimulation on idopathic epilepsy in a NHP implanted with a sensing enabled DBS device, as well as studying data generated from epilepsy patients implanted with the RNS device.

GABAegic Innervation of Human Epileptic Hippocampus
The lab has built a large brain bank of en bloc hippocampal specimens resected during epilepsy surgery. Current studies are focused on defining bouton-level alterations in GABAerigic innervation of dentate granule cell neurons.

[See Intraoperative Electrode Localization Tool.]

For more detailed information on the Brain Modulation Laboratory, please visit brainmodulationlab.org.

We are indebted to our epilepsy and movement disorder patients who allow the use of their clinical data to benefit neuroscience and to potentially help future patients.