Funding Agency:

SPAWAR Systems Center Pacific (Grant No. SA 07295-01)

Total Project Period:

03/19/10 - 04/15/12     

Total Project Award:

(To Department of Neurological Surgery)
$221,050

Principal Investigator:

Patrick M. Kochanek, MD (Critical Care Medicine)

Co-Investigators:

Larry W. Jenkins, PhD; Hulya Bayir, MD, Robert Clark, MD, C. Edward Dixon, PhD, Edwin Jackson, PhD, Valerian Kagan, PhD

Project Summary:

This proposal represents one of the projects within a large programmatic effort -- centered at the Walter Reed Army Institute of Research (WRAIR) -- to develop new therapies, preventative, resuscitative, and reparative for traumatic brain injury secondary to blast injury.

This program is being formed in response to the great need for new strategies for this problem as it escalates from terrorist attacks with improvised explosive devices.

The work that will be done at the Safar Center for Resuscitation Research will entail biochemical, molecular, and cellular analysis of brain samples from rats and pigs studied at WRAIR in a proposed two year program. We propose to identify new targets for therapy and evaluate effectiveness of novel therapeutic approaches.