Funding Agency:

National Institute of Health

Total Project Period:

09/01/04 - 08/31/09

Total Project Award:

$51,076

Principal Investigator:

Amy Wagner, PhD
(Physical Medicine & Rehabilitation)

Co-Investigator:

Anthony Fabio, PhD

Project Summary:

The goal of this proposal is to investigate whether potentially relevant DAergic candidate genes influence cognitive and behavioral outcomes for persons with moderate to severe TBI.

Additionally we are using PET imaging techniques to investigate

1. the effects of TBI of DAT/D2 binding and kinetics and the role of DAT/D2 genotype in mediating potential differences in receptor binding,
2. the relationship between striatal DAT/D2 binding and cognitive deficits post-TBI, and
3. the roles of DAT/D2 genotype in mediating the efficacy of MPD treatment on neuropsychological function.