Funding Agency:

National Institutes of Health, National Institute of Neurological Disorders and Stroke (Grant No. 1 R01 NS37704)

Total Project Period:

09/01/98 - 2/28/10

Total Project Award:

$1,336,500

Principal Investigator:

Ian F. Pollack, MD

Co-Investigators:

Ronald L. Hamilton, MD (Department of Pathology), Robert Sobol, MD.

Project Summary:

The proposed studies will use microdissected tumor tissue as well as newly acquired tumor specimens and paired normal tissue, derived from 200 children treated on two new Children's oncology group high-grade glioma studies, to examine the influence of drug resistance markers and additional genotypic features on treatment response in pediatric malignant gliomas, as a basis for refining the accuracy of prognostic assessments.