Funding Agency:

National Institute of Health

Total Project Period:

04/21/06 - 02/28/2011

Total Project Award:

$742,500

Principal Investigator:

Joseph Glorioso, PhD
(Molecular Genetics and Biochemistry)

Co-Investigator:

Paola Grandi, PhD

Project Summary:

Experiments are outlined to explore methods to enhance the potency of HSV oncolytic vectors through improved vector distribution within the tumor mass, the testing of additional mutant vector backbones whose performance may be improved by enhanced and more specific intra-tumoral replication an through the use of additional transgenes that may be more effective in destruction of the tumor mass including lovally infiltrating tumor cells into normal brain tissue.

Throughout this investigation vector performance and tumor killing will be evaluated in combination with radiosurgery. We will use the performance of G207 as a benchmark with which to compare any vector improvements.