Funding Agency:

National Institutes of Health

Total Project Period:

5/15/07 - 4/30/13

Total Project Award:

$11,076,349

Principal Investigator:

P. David Adelson, MD

Co-Investigators:

Anthony Fabio, PhD, Stephen R. Wisniewski, PhD, Sue Beers, PhD

Project Summary:

The primary hypothesis for this application is for a multicenter Phase III Randomized Clinical Trial (RCT) to induce moderate HYPO (32-33oC) after severe TBI in children and maintained for 48 hours will imporve mortality and 3, 6 and 12 mos functional outcomes in children as assessed by the Glasgow Outcome Scale-Extended (GOS/GOS-E).