2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000

2006

Bayir H, Kochanek PM, Kagan VE: Oxidative stress in immature brain after traumatic brain injury. Dev Neurosci 28(4-5):420-31, 2006.

Bayir H, Fadeel B, Palladino MJ, Witasp E, Kurnikov IV, Tyurina YY, Tyurin VA, Amoscato AA, Jiang J, Kochanek PM, DeKosky ST, Greenberger JS, Shvedova AA, Kagan VE: Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria. Biochim Biophys Acta 1757(5-6):648-59, 2006. [Epub 2006 Mar 31.] Review.

Berger RP, Kochanek PM: Urinary S100B concentrations are increased after brain injury in children: A preliminary study. Pediatr Crit Care Med 9:26, 2006. [Epub ahead of print]

Berger RP: The use of serum biomarkers to predict outcome after traumatic brain injury in adults and children. J Head Trauma Rehabil 21(4):315-33, 2006. Review.

Berger RP, Dulani T, Adelson PD, Leventhal JM, Richichi R, Kochanek PM: Identification of inflicted traumatic brain injury in well-appearing infants using serum and cerebrospinal markers: a possible screening tool. Pediatrics 117(2):325-32, 2006.

Clark RS, Nathaniel PD, Zhang X, Dixon CE, Alber SM, Watkins SC, Melick JA, Kochanek PM, Graham SH: boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. J Cereb Blood Flow Metab 5:17, 2006 [Epub ahead of print]

Cousar JL, Lai Y, Marco CD, Bayir H, Adelson PD, Janesko-Feldman KL, Kochanek PM, Clark RS: Heme oxygenase 1 in cerebrospinal fluid from infants and children after severe traumatic brain injury. Dev Neurosci 28(4-5):342-7, 2006.

Gao WM, Chadha MS, Kline AE, Clark RS, Kochanek PM, Dixon CE, Jenkins LW: Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats. Brain Res 27;1070(1):31-4, 2006. [Epub 2006 Jan 9.]

Kerr ME, Kamboh MI, Kong Y, Alexander S, Yonas H: Apolipoprotein E genotype and CBF in traumatic brain injured patients. Adv Exp Med Biol 578:291-6, 2006.

Kochanek PM: Pediatric traumatic brain injury: quo vadis? Dev Neurosci 28(4-5):244-55, 2006.

Kochanek AR, Kline AE, Gao WM, Chadha M, Lai Y, Clark RS, Dixon CE, Jenkins LW: Gel-based hippocampal proteomic analysis 2 weeks following traumatic brain injury to immature rats using controlled cortical impact. Dev Neurosci 28(4-5):410-9, 2006.

Kochanek PM, Vagni VA, Janesko KL, Washington CB, Crumrine PK, Garman RH, Jenkins LW, Clark RS, Homanics GE, Dixon CE, Schnermann J, Jackson EK: Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury. J Cereb Blood Flow Metab 26(4):565-75, 2006.

Lai Y, Stange C, Wisniewski SR, Adelson PD, Janesko-Feldman KL, Brown DS, Kochanek PM, Clark RS: Mitochondrial heat shock protein 60 is increased in cerebrospinal fluid following pediatric traumatic brain injury. Dev Neurosci 28(4-5):336-41, 2006.

Minster RL, Dekosky ST, Kamboh MI: Lack of association of two chromosome 10q24 SNPs with Alzheimer's disease. Neurosci Lett 9:23,2006 [Epub ahead of print]

Nemoto EM, Rao G, Robinson T, Saunders T, Kirkman J, Davis D, Kuwabara H, Dixon CE. Effect of local cooling (15 degrees C for 24 hours) with the Chillerpad after traumatic brain injury in the nonhuman primate. Adv Exp Med Biol 578:311-5, 2006.

Ozturk A, Minster RL, Dekosky ST, Kamboh MI: Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits. Am J Med Genet B Neuropsychiatr Genet 9:11, 2006. [Epub ahead of print]

Pardes Berger R, Adelson PD, Richichi R, Kochanek PM: Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injury. Dev Neurosci 28(4-5):327-35, 2006.

Poloyac SM, Zhang Y, Bies RR, Kochanek PM, Graham SH: Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. J Cereb Blood Flow Metab 3:29;2006. [Epub ahead of print]

Shore PM, Hand LL, Roy L, Trivedi P, Kochanek PM, Adelson PD: Reliability and validity of the Pediatric Intensity Level of Therapy (PILOT) scale: a measure of the use of intracranial pressure-directed therapies. Crit Care Med 34(7):1981-7, 2006.

Statler KD, Alexander H, Vagni V, Dixon CE, Clark RS, Jenkins L, Kochanek PM: Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. J Neurotrauma 23(1):97-108, 2006.

Statler KD, Alexander H, Vagni V, Holubkov R, Dixon CE, Clark RS, Jenkins L, Kochanek PM: Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury. Brain Res 3;1076(1):216-24, 2006. [Epub 2006 Feb 13.]

Tehranian R, Rose ME, Vagni V, Griffith RP, Wu S, Maits S, Zhang X, Clark RS, Dixon CE, Kochanek PM, Bernard O, Graham SH: Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury. Brain Res 26;1101(1):126-35, 2006. [Epub 2006 Jun 19.]

Tyurina YY, Kapralov AA, Jiang J, Borisenko GG, Potapovich AI, Sorokin A, Kochanek PM, Graham SH, Schor NF, Kagan VE: Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells. Brain Res 6;1093(1):71-82, 2006. [Epub 2006 May 18.]

Wu X, Drabek T, Kochanek PM, Henchir J, Stezoski SW, Stezoski J, Cochran K, Garman R, Tisherman SA: Induction of profound hypothermia for emergency preservation and resuscitation allows intact survival after cardiac arrest resulting from prolonged lethal hemorrhage and trauma in dogs. Circulation 25;113(16):1974-82, 2006. [Epub 2006 Apr 17.]

2005

Abrahamson EE, Ikonomovic MD, Ciallella JR, Hope CE, Paljug WR, Isanski BA, Flood DG, Clark RSB, DeKosky ST. Caspase inhibition therapy abolishes brain trauma-induced increases in Aß peptide: Implications for clinical outcome. Exp Neurol 2005 Nov 18; [Epub ahead of print]

Adelson PD, Ragheb J, Muizelaar JP, Duhaime A, Johnson D, Kanew P, Brockmeyer D, Beers SR, Brown SD, Cassidy L, Chang Y, Levin H:  A phase II clinical trial of moderate hypothermia following severe traumatic brain injury in children.  Neurosurgery 56(4) 740-54, 2005.

Bayir H, Kagan VE, Borisenko G, Tyurina YY, Janesko K, Vagni V, Billiar TR, Williams D, Kochanek PM:  Enhanced oxidative stress in iNOS deficient mice after traumatic brain injury: Support for a neuroprotective role of iNOS.  J Cereb Blood Flow Metab 16:1-12, 2005.

Beers SR, Skold A, Dixon CE, Adelson PD: Neurobehavioral Effects of amantadine after pediatric traumatic brain injury: A preliminary report. J Head Trauma Rehabit 20(5):450-63, 2005.

Berger RP, Adelson PD, Pierce MC, Dulani T, Cassidy LD, Kochanek PM. Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. J Neurosurg 103:61-8, 2005.

Card JP, Santone DJ, Gluhovsky MY, Adelson PD. Plastic reorganization of hippocampal and neocortical circuitry in experimental traumatic brain injury in the immature rat. J Neurotrauma 22(9):989-1002, 2005.

Chen X, Li Y, Kline AE, Dixon CE, Zafonte RD, Wagner AK: Gender and environmental effects on regional brain-derived neurotrophic factor expression after experimental traumatic brain injury. Neuroscience 135(1):11-7, 2005.

Fink EL, Marco CD, Donovan HA, Alexander H, Dixon CE, Jenkins LW, Stange CJ, Kochanek PM, Clark RS: Brief induced hypothermia improves outcome after asphyxial cardiopulmonary arrest in juvenile rats. Dev Neurosci 27(2-4):191-9, 2005.

Foley LM, Hitchens TK, Kochanek PM, Melick JA, Jackson EK, Ho C: Murine orthostatic response during prolonged vertical studies: Effect on cerebral blood flow measured by arterial spin-labeled MRI. Magn Reson Med 54(4):798-806, 2005.

Kochanek PM, Hendrich KS, Jackson EK, Wisniewski SR, Melick JA, Shore PM, Janesko KL, Ho C: Characterization of the effects of adenosine receptor agonists on cerebral blood flow in uninjured and traumatically injured rat brain using continuous arterial spin-labeled magnetic resonance imaging. J Cereb Blood Flow Metab 25(12):1596-1612, 2005.

Kochanek PM, Vagni VA, Janesko KL, Washington CB, Crumrine PK, Garman RH, Jenkins LW, Clark RS, Homanics GE, Dixon CE, Schnermann J, Jackson EK: Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury. J Cereb Blood Flow Metab Aug 24;2005 [Epub ahead of print]

Kraus MF, Smith GS, Butters M, Donnell AJ, Dixon CE, Yilong C, Marion DW: Effects of the dopaminergic agent and NMDA receptor antagonist amantadine on cognitive function, cerebral glucose metabolism and D2 receptor availability in chronic traumatic brain injury: a study using positron emission tomography (PET). Brain Injury 19(7):471-9, 2005.

Lai Y, Du L, Dunsmore KE, Jenkins LW, Wong HR, Clark RS: Selectively increasing inducible heat shock protein 70 via TAT-protein transduction protects neurons from nitrosative stress and excitotoxicity. J Neurochem 94(2):360-6, 2005.

Satchell MA, Lai Y, Kochanek PM, Wisniewski SR, Fink EL, Siedberg NA, Berger RP, DeKosky ST, Adelson PD, Clark RSB: Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuse. J Cereb Blood Flow Metab 25(7) 919-27, 2005.

Saxton J, Kastango KB, Hugonot-Diener L, Boller F, Verny M, Sarles CE, Girgis RR, Devouche E, Mecocci P, Pollock BG, DeKosky ST. Development of a short form of the Severe Impairment Battery. Am J Geriatr Psychiatry. 13(11):999-1005, 2005.

Statler KD, Alexander HL, Dixon CE, Vagni V, Dixon CE, Clark RSB, Jenkins L, Kochanek PM: Comparison of seven anesthetics on outcome after traumatic brain injury by controlled cortical impact in adult, male rats. J Neurotrauma (in press).

Tilford JM, Aitken ME, Anand KJ, Green JW, Goodman AC, Parker JG, Killingsworth JB, Fiser DH, Adelson PD.Hospitalizations for critically ill children with traumatic brain injuries: A longitudinal analysis. Crit Care Med 33(9):2074-2081, 2005.

Tortorici M, Kochanek PM, Bies RR, Poloyac SM: Therapeutic hypothermia induced pharmacokinetic alterations on CYP2E1 chlorzoxazone mediated metabolism in a cardiac arrest rat model. Crit Care Med (in press).

Wagner AK, Chen X, Kline AE, Li Y, Zafonte RD, Dixon CE: Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injury. Exp Neurol Jul 13;2005 [Epub ahead of print]

Wagner AK, Sokoloski JE, Ren D, Chen X, Khan AS, Zafonte RD, Michael AC, Dixon CE: Controlled cortical impact injury affects dopaminergic transmission in the rat striatum. J Neurochem. 95(2):457-65, 2005.

Wilson MS, Chen X, Ma X, Ren D, Wagner AK, Reynolds IJ, Dixon CE:  Synaptosomal dopamine uptake in rat striatum following controlled cortical impact.  J Neurosci Res 80(1):85-91, 2005.

Wu X, Kochanek PM, Cochran K, Nozari A, Henchir J, Stezoski SW, Wagner R, Wisniewski S, Tisherman SA: Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. J Trauma 59(2):291-9, 2005.

Zhang X, Chen Y, Jenkins LW, Kochanek PM, Clark RS.  Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury.  Crit Care 9(1):66-75, 2005.

Zhang X, Chen Y, Ikonomovic MD, Nathaniel PD, Kochanek PM, Marion DW, DeKosky ST, Jenkins LW, Clark RSB: Increased phosphorylation of protein kinase B and its substrates after traumatic brain injury in humans and rats. J Cereb Blood Flow Metab 2005 Oct 19; [Epub ahead of print]

2004

Alexander S, Kerr ME, Yonas H, Marion DW:  The Effects of Admission Alcohol Level on Cerebral Blood Flow and Outcomes after Severe Traumatic Brain Injury.  J Neurotrauma 21(5):575-83, 2004.

Bayir H, Marion DW, Puccio AM, Wisniewski SR, Janesko KL, Clark RSB, Kochanek PM:  Marked Gender Effect on Lipid Peroxidation after Severe Traumatic Brain Injury in Adult Patients.  J Neurotrauma 21(1):1-8, 2004.

Berger RP, Heyes MP, Wisniewski SR, Adelson PD, Thomas N, Kochanek PM:  Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuse.  J Neurotrauma 21(9):1123-30, 2004.

Berger RP, Kochanek PM, Pierce MC:  Biochemical markers of brain injury: could they be used as diagnostic adjuncts in cases of inflicted traumatic brain injury? Child Abuse Negl 28(7):739-54, 2004.

DeKosky ST, Abrahamson EE, Taffe KM, Dixon CE, Kochanek PM, Ikonomovic MD:  Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies.  J Neurochem 90:998-1004, 2004.

DeKosky ST, Taffe KM, Abrahamson EE, Dixon CE, Kochanek PM, Ikonomovic MD:  Time Course Analysis of Hippocampal Nerve Growth Factor and Antioxidant Enzyme Activity following Lateral Controlled Cortical Impact Brain Injury in the Rat.  J Neurotrauma 21(5) 491-500, 2004.

Du L, Bayir H, Lai Y, Zhang Z, Kochanek PM, Watkins SC, Graham SH, Clark RSB: Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway.  J Biol Chem 279:38563-38570, 2004.

Fink EL, Alexander H, Marco CD, Dixon CE, Kochanek PM, Jenkins LW, Lai Y, Donovan HA, Hickey RW, Clark RS. Experimental model of pediatric asphyxial cardiopulmonary arrest in rats.  Pediatr Crit Care Med 5(2):139-144,2004.

Grenvik A, Kochanek PM:  The incredible career of Peter J. Safar, MD: the Michelangelo of acute medicine.  Crit Care Med 32(2 Suppl):S3-7, 2004.

Ikonomovic MD, Uryu K, Abrahamson EE, Ciallella JR, Trojanowski JQ, Lee VM-Y, Clark RSB, Marion DW, Wisniewski SR, DeKosky ST:  Alzheimer’s pathology in human temporal cortex surgically excised after severe brain injury.  Exp Neurol  190:92-203, 2004.

Jiang J, Borisenko GG, Osipov A, Martin I, Chen R, Shvedova AA, Sorokin A, Tyurina YY, Potapovich A, Tyurin VA, Graham SH, Kagan VE:  Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells.  J Neurochem 90:1036-49, 2004.

Kline AE, Massucci JL, Dixon CE, Zafonte RD, Bolinger BD:  The Therapeutic Efficacy Conferred by the 5-HT1A Receptor Agonist 8-Hydroxy- 2-(di-n-propylamino)tetralin (8-OH-DPAT) after Experimental Traumatic Brain Injury Is Not Mediated by Concomitant Hypothermia. J Neurotrauma 21(2):175-85, 2004. 

Kline AE, Massucci JL, Ma X, Zafonte RD, Dixon CE:  Bromocriptine reduces lipid peroxidation and enhances spatial learning and hippocampal neuron survival in a rodent model of focal brain trauma.  Neurotrauma 21(12):1712-22, 2004.

Lai Y, Kochanek PM, Adelson PD, Janesko K, Ruppel RA, Clark RSB:  Induction of the Stress Response after Inflicted and Non-Inflicted Traumatic Brain Injury in Infants and Children.  J Neurotrauma 21(3) 229-37, 2004

Massucci JL, Kline AE, Ma X, Zafonte RD, Dixon CE:  Time dependent alterations in dopamine tissue levels and metabolism after experimental traumatic brain injury in rats.  Neurosci Lett 372:127-131, 2004.

Shore PM, Thomas NJ, Clark RS, Adelson PD, Wisniewski SR, Janesko KL, Bayir H, Jackson EK, Kochanek PM:  Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers. J Neurotrauma 21(9):1113-22, 2004.

Shore PM, Jackson EK, Wisniewski S, Clark RSB, Adelson PD, Kochanek PM:  Vascular endothelial growth factor is increased in cerebrospinal fluid after traumatic brain injury in infants and children.  Neurosurgery 54(3):605-11, 2004.

Wagner AK, Willard LA, Kline AE, Wenger MK, Bolinger BD, Ren D, Zafonte RD, Dixon CE:  Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injury.  Brain Res 998(1):113-21, 2004.

Wagner AK, Bayir H, Ren D, Puccio AM, Zafonte RD, Kochanek PM:  Relationships between Cerebrospinal Fluid Markers of Excitotoxicity, Ischemia, and Oxidative Damage after Severe TBI: The Impact of Gender, Age, and Hypothermia.  J Neurotrauma 21(2):125-136, 2004.

Wu S, Zhou L, Rose M, Xiao X, Graham SH:  c-FLIP-L recombinant adeno-associated virus vector infection prevents Fas-mediated but not nerve growth factor withdrawal-mediated cell death in PC12 cells.  Mol Brain Res 122(1):79-87, 2004.

Wu Chen R, Zhang Y, Rose ME, Graham SH:  Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo.  Mol Brain Res 132(1):31-7, 2004

2003

Bayir H, Clark RS, Kochanek PM: Promising strategies to minimize secondary brain injury after head trauma. Crit Care Med 31(1 Suppl):S112-7, 2003. (Review)

Bayir H, Kochanek PM, Clark RS: Traumatic brain injury in infants and children: mechanisms of secondary damage and treatment in the intensive care unit. Crit Care Clin 19(3):529-49, 2003. (Review)

Bayir H, Kochanek PM, Liu SX, Arroyo A, Osipov A, Jiang J, Wisniewski S, Adelson PD, Graham SH, Kagan VE: Increased S-nitrosothiols and S-nitrosoalbumin in cerebrospinal fluid after severe traumatic brain injury in infants and children: indirect association with intracranial pressure. J Cereb Blood Flow Metab 23(1):51-61, 2003.

Behringer W, Safar P, Wu X, Kentner R, Radovsky A, Kochanek PM, Dixon CE, Tisherman SA: Survival without brain damage after clinical death of 60-120 min in dogs using suspended animation by profound hypothermia. Crit Care Med 31(5):1523-1531, 2003.

Cao G, Clark RS, Pei W, Yin W, Zhang F, Sun FY, Graham SH, Chen J: Translocation of Apoptosis-Inducing Factor in Vulnerable Neurons After Transient Cerebral Ischemia and in Neuronal Cultures After Oxygen-Glucose Deprivation. J Cereb Blood Flow Metab 23(10):1137-1150, 2003.

Chen D, Jin K, Kawaguchi K, Nakayama M, Zhou X, Xiong Z, Zhou A, Mao XO, Greenberg DA, Graham S. H., Simon RP. Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism. J Neurochem 85:670-679, 2003.

Dixon CE, Ma X, Kline AE, Yan HQ, Ferimer H, Kochanek PM, Wisniewski SR, Jenkins LW, Marion DW: Acute etomidate treatment reduces cognitive deficits and histopathology in rats with traumatic brain injury. Crit Care Med 31(8):2222-7, 2003.

Du L, Zhang X, Han YY, Burke NA, Kochanek PM, Watkins SC, Graham SH, Carcillo JA, Szabo C, Clark RS: Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress. J Biol Chem 278(20):18426-33, 2003.

Graham S. H., Hickey RW. Cyclooxygenases in central nervous system diseases: a special role for cyclooxygenase 2 in neuronal cell death. Arch Neurol 60:628-630, 2003.

Hickey RW, Kochanek PM, Ferimer H, Alexander HL, Garman RH, Graham S. H.. Induced hyperthermia exacerbates neurologic neuronal histologic damage after asphyxial cardiac arrest in rats. Crit Care Med 31(2):531-5, 2003.

Kay AD, Petzold A, Kerr M, Keir G, Thompson EJ, Nicoll JA: Cerebrospinal fluid apolipoprotein E concentration decreases after traumatic brain injury. J Neurotrauma 20(3):243-50, 2003.

Kerr ME, Ilyas Kamboh M, Yookyung K, Kraus MF, Puccio AM, DeKosky ST, Marion DW: Relationship between apoE4 allele and excitatory amino acid levels after traumatic brain injury. Crit Care Med 31(9):2371-9, 2003.

Kochanek PM, Safar PJ: Therapeutic hypothermia for severe traumatic brain injury. JAMA 11:289(22):3007-9, 2003.

Koldamova RP, Lefterov IM, Ikonomovic MD, Skoko J, Lefterov PI, Isanski BA, DeKosky ST, Lazo JS: 22R-Hydroxycholesterol and 9-cis-retinoic acid induce ABCA1 transporter expression and cholesterol efflux in brain cells and decrease Ab secretion. J Biol Chem 278(15):13244-13256, 2003.

Liou AK, Clark RS, Henshall DC, Yin XM, Chen J: To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog Neurobiol 69(2):103-42, 2003. (Review)

Satchell MA, Zhang X, Kochanek PM, Dixon CE, Jenkins LW, Melick J, Szabo C, Clark RS: A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma. J Neurochem 85(3):697-708, 2003.

Seidberg NA, Clark RS, Zhang X, Lai Y, Chen M, Graham SH, Kochanek PM, Watkins SC, Marion DW: Alterations in inducible 72-kDa heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury. J Neurochem 84(3):514-21, 2003.

Statler KD, Alexander HL, Vagni VA, Nemoto EM, Tofovic SP, Dixon CE, Jenkins LW, Marion DW, Kochanek PM: Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats. Crit Care Med 31(4):1134-9, 2003.

Statler KD, Janesko KL, Melick JA, Clark RS, Jenkins LW, Kochanek PM: Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats. Brain Res 994(1):37-43, 2003.

Varma S, Janesko KL, Wisniewski SR, Bayir H, Adelson PD, Thomas NJ, Kochanek PM. F2-isoprostane and neuron-specific enolase in cerebrospinal fluid after severe traumatic brain injury in infants and children. J Neurotrauma 20(8):781-6, 2003.

Wagner AK, Fabio T, Zafonte RD, Goldberg G, Marion DW, Peitzman AB: Physical medicine and rehabilitation consultation: relationships with acute functional outcome, length of stay, and discharge planning after traumatic brain injury. Am J Phys Med Rehabil 82(7):526-36, 2003.

Wu X, Stezoski J, Safar P, Bauer A, Tuerler A, Schwarz N, Kentner R, Behringer W, Kochanek PM, Tisherman SA: Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responses. Crit Care Med 31(1):195-202, 2003.

Zhang X, Graham SH, Kochanek PM, Marion DW, Nathaniel PD, Watkins SC, Clark RS: Caspase-8 expression and proteolysis in human brain after severe head injury. FASEB J 17(10):1367-9, 2003.

2002

Basu A, Krady JK, O'Malley M, Styren SD, DeKosky ST, Levison SW: The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. Neurosci 22(14):6071-82, 2002.

Bayir H, Kagan VE, Tyurina YY, Tyurin V, Ruppel RA, Adelson PD, Graham SH, Janesko K, Clark RS, Kochanek PM: Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatr Res 51(5):571-8, 2002

Behringer W, Safar P, Kentner R, Wu X, Kagan VE, Radovsky A, Clark RSB, Kochanek PM, Subramanian M, Tyurin VA, Tyurina YY, Tisherman SA: Antioxidant tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs. J Cereb Blood Flow Metab 22(1):105-117, 2002.

Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Clark RS, Ruppel RA, Kochanek PM: Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics 109(2):E31, 2002.

Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Kochanek PM. Serum S100B concentrations are increased after closed head injury in children: a preliminary study. J Neurotrauma 19(11):1405-9, 2002.

Ciallella JR, Ikonomovic MD, Paljug WR, Wilbur YI, Dixon CE, Kochanek PM, Marion DW, DeKosky ST: Changes in expression of amyloid precursor protein and interleukin-1_ after experimental traumatic brain injury in rats. J Neurotrauma 19(12):1555-67, 2002.

Clark RS: Out of the frying pan and into the fire: Neurodevelopmental outcome in pediatric intensive care unit survivors of serious brain injury. Pediatr Crit Care Med 3(4):384-5, 2002. (Editorial)

Gao W-M, Lu H-M, Dong J-C, Zhang W, Zhou X-Y, Jenkins LW, Dixon CE. Postnatal growth, neurobehavioral and neurophysiologic changes of prenatal low-dose beta radiation from tritiated water in mice. Neurotoxicol Teratol 24(2):247-254, 2002.

Han YH, Carcillo JA, Ruppel RA, Adelson PD, Wisniewski SR, Bell MJ, Janesko KL, Marion DW, Kochanek PM: Cerebrospinal fluid procalcitonin is increased after traumatic brain injury in children. Pediatr Crit Care Med 3(1):39-44, 2002.

Jenkins LW, Peters GW, Dixon CE, Zhang X, Clark RS, Skinner JC, Marion DW, Adelson PD, Kochanek PM: Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats. J Neurotrauma 19(6):715-40, 2002.

Kline AE, Bolinger BD, Kochanek PM, Carlos TM, Yan HQ, Jenkins LW, Marion DW, Dixon CE: Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats. Brain Res 24;937(1-2):22-31, 2002.

Kline AE, Massucci JL, Marion DW, Dixon CE: Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury by controlled cortical impact. J Neurotrauma 19(4):415-25, 2002.

line AE, Yu J, Massucci JL, Zafonte RD, Dixon CE: Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats. Neurosci Lett 333(3):179-82, 2002.

Kochanek PM, Hendrich KS, Dixon CE, Schiding JK, Williams DS, Ho C: Cerebral blood flow at one year after controlled cortical impact in rats: assessment by magnetic resonance imaging. J Neurotrauma 19(9):1029-37, 2002.

MacKenzie EJ, McCarthy ML, Ditunno JF, Forrester-Staz C, Gruen GS, Marion DW, Schwab WC: Using the SF-36 for characterizing outcome following multiple trauma involving head injury. J Trauma 52(3):527-534, 2002.

Marion DW, Puccio A, Wisniewski SR, Kochanek P, Dixon CE, Bullian L, Carlier P: Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury. Crit Care Med 30(12):2619-25, 2002.

Marion DW: Moderate hypothermia in severe head injuries: the present and the future. Curr Opin Crit Care 8(2):111-14, 2002. (Review)

Marion DW: Is it poly(adenosine 5'-diphosphate-ribose) polymerase or hypothermia? Crit Care Med 30(11):2595-6, 2002. (Editorial)

Marion DW: Increasing blood pressure causes a decrease in intracranial pressure in patients with brain injury. Crit Care Med 30(7):1671-2, 2002. (Review)

Marion DW: Cytokines and therapeutic hypothermia. Crit Care Med 30(7): 1666-7, 2002. (Editorial)

Mori T, Wang X, Jung, J-C, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH: Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab 22:444-452, 2002.

Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, Bullock MR, Choi SC, Clifton GL, Contant CF, Coplin WM, Cietrich WD, Ghajar J, Grady SM, Grossman RG, Hall ED, Heetderks W, Hovda DA, Jallo J, Katz RL, Knoller N, Kochanek PM, Maas AI, Majde J, Marion DW, Marmarou A, Marshall LF, McIntosh TK, Miller E, Mohberg N, Muizelaar JP, Pitts LH, Quinn P, Riesenfeld G, Robertson CS, Strauss KI, Teasdale G, Temkin N, Tuma R, Wade C, Walker MD, Weinrich M, Whyte J, Wilberger J, Young AB, Yurkewicz L: Clinical Trials in Head Injury. J Neurotrauma 19(5):503-557, 2002.

Ray SK, Dixon CE, Banik NL: Molecular mechanisms in the pathogenesis of traumatic brain injury. Histol Histopathol 17(4):1137-52, 2002. (Review)

Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, Kochanek PM, Graham SH: Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res 943(1):15-22, 2002.

Ruppel RA, Clark RS, Bayir H, Satchell MA, Kochanek PM: Critical mechanisms of secondary damage after inflicted head injury in infants and children. Neurosurg Clin N Am 13(2):169-82, v., 2002. (Review)

Varma MR, Dixon CE, Jackson EK, Peters GW, Melick JA, Griffith RP, Vagni VA, Clark RS, Jenkins LW, Kochanek PM: Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology. Brain Res 951(2):191-201, 2002.

Wagner AK, Kline AE, Sokoloski J, Zafonte RD, Capulong E, Dixon CE: Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats. Neurosci Lett 334(3):165-8, 2002.

Weber BB, Kerr ME, Wechsler LR, Marion DW: Absence of a diastolic velocity notch does not indicate hyperemia in traumatic brain injured patients without elevated cerebral blood flow velocity. J Neurosurg Anesthesiol 14(4):279-86, 2002.

Wu X, Stezoski J, Safar P, Behringer W, Kentner R, Kochanek PM, Tisherman SA: Systemic hypothermia, but not regional gut hypothermia, improves survival from prolonged hemorrhagic shock in rats. J Trauma 53:654-662, 2002.

Yan HQ, Kline AE, Ma X, Li Y, Dixon CE: Traumatic brain injury reduces dopamine transporter protein expression in the rat frontal cortex. Neuroreport 13(15):1899-901, 2002.

Zhang X, Chen J, Graham SH, Du L, Kochanek PM, Draviam R, Guo F, Nathaniel PD, Szabo C, Watkins SC, Clark RS: Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem 82(1):181-91, 2002.

2001

Amick JE, Yandora KA, Janesko K, Adelson PD, Ruppel RA, Clark RSB, Marion DW, DeKosky ST, Kochanek PM: TH1 versus TH2 cytokine profiles in cerebrospinal fluid after severe traumatic brain injury in children. Pediatr Crit Care Med 2(3):260-264, 2001.

Bell MJ, Robertson CS, Kochanek PM, Goodman JC, Gopinath SP, Carcillo JA, Clark RS, Marion DW, Mi Z, Jackson EK: Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury. Crit Care Med 29(2): 399-404, 2001.

Burke JP, Marion DW: Cerebral revascularization in trauma and carotid occlusion. Neurosurg Clin N Am 12(3):595-611, ix., 2001. (Review)

Clark RSB, Chen M, Kochanek PM, Watkins SC, Jin KL, Draviam R, Nathaniel PD, Pinto R, Marion DW, Graham SH: Detection of single- and double-strand DNA breaks after traumatic brain injury in rats: comparison of in situ labeling techniques using DNA polymerase I, the Klenow fragment of DNA polymerase I, and terminal deoxynucleotidyl transferase. J Neurotrauma 18(7):675-689, 2001.

Hendrich KS, Kochanek PM, Melick JA, Schiding JK, Statler KD, Williams DS, Marion DW, Ho C.: Cerebral perfusion during anesthesia with fentanyl isoflurane or pentobarbital in normal rats studied by arterial spin-labeled MRI. Magn Reson Med 46(1):202-206, 2001.

Kline AE, Yu J, Horvath E, Marion DW, Dixon CE: The selective 5-HT(1A) receptor agonist repinotan HCl attenuates histopathology and spatial learning deficits following traumatic brain injury in rats. Neuroscience 106(3):547-55, 2001.

Kochanek PM, Hendrich KS, Robertson CL, Williams DS, Melick JA, Ho C, Marion DW, Jackson EK: Assessment of the effect of 2-chloroadenosine on cerebral blood flow in normal rats using arterial spin labeled MRI. Magn Reson Med 45(5):924-929, 2001

Kochanek PM, Janesko KL, Jenkins LW, Yan HQ, Kibbe MR, Robichaud P, Clark RSB, Dixon CE, Marion DW, Billiar TR: Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice. J Neurotrauma 18(1):73-82, 2001.

Marion DW: Therapeutic moderate hypothermia and fever. Invited Review. Curr Pharm Des 7:1533-1536, 2001. (Review)

Robertson CL, Bell MJ, Kochanek PM, Adelson PD, Ruppel RA, Carcillo JA, Wisniewski SR, Mi Z, Janesko KL, Clark RS, Marion DW, Graham SH, Jackson EK: Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity. Crit Care Med 29(12):2287-93, 2001.

Robertson CL, Minamino N, Ruppel RA, Kangawa K, Wisniewski SR, Tsuji T, Janesko KL, Ohta H, Adelson PD, Marion DW, Kochanek PM: Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in infants and children. J Neurotrauma 18(9):861-8, 2001.

Ruppel RA, Kochanek PM, Adelson PD, Rose ME, Wisniewski SR, Bell MJ, Clark RS, Marion DW, Graham SH: Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse. J Pediatr 138(1):18-25, 2001.

Statler KD, Jenkins L, Dixon CE, Clark RSB, Marion DW, Kochanek PM: The simple model vs. the super model: Translating experimental traumatic brain injury research to the bedside. J Neurotrauma 18:1195-1206, 2001.

Yan HQ, Kline AE, Ma X, Hooghe-Peters EL, Marion DW, Dixon CE: Tyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injury. Neuroreport 12(11):2323-7, 2001.

2000

Clark RS, Kochanek PM, Watkins SC, Chen M, Dixon CE, Seidberg NA, Melick J, Loeffert JE, Nathaniel PD, Jin KL, Graham SH: Caspase-3 mediated neuronal death after traumatic brain injury in rats. J Neurochem 74(2):740-753, 2000.

Clark RSB, Kochanek PM, Adelson PD, Bell MJ, Carcillo JA, Chen M, Wisniewski SR, Janesko K, Whalen MJ, Graham SH: Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed-cell death in infants and children following severe traumatic brain injury. J Pediatr, 137(2):197-204, 2000.

Henshall DC, Clark RSB, Adelson PD, Chen M, Watkins SC, Simon RP: Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy. Neurology 55(2):250-257, 2000.

Hickey RW, Kochanek PM, Ferimer H, Graham SH, Safar P: Hypothermia and hyperthermia in children after resuscitation from cardiac arrest. Pediatrics 106(1):118-122, 2000.

Hickey RW, Zhu R, Alexander HL, Jin KL, Stetler RA, Chen J Kochanek PM Graham SH: 10 kD mitochondrial matrix heat shock protein mRNA is induced following global brain ischemia in the rat. Mol Brain Res 79(1-2):169-173, 2000.

Hickey RW, Ferimer H, Alexander HL, Garman RH, Callaway CW, Hicks S, Safar P, Graham SH, Kochanek PM: Delayed, spontaneous hypothermia reduces neuronal damage after asphyxial cardiac arrest in rats. Crit Care Med 28(10):3511-3516, 2000.

Ikonomovic MD, Nocera R, Mizukami K, Armstrong DM: Age-related loss of the MPA receptor subunits GluR2/3 in the human nucleus basalis of Meynert. Exp Neurol 166(2):363-375, 2000.

Kanno S, Lee PC, Zhang Z, Ho C, Griffith BP, Shears II LL, Billiar TR: Attenuation of myocardial ischemia/reperfusion injury by superinduction of inducible nitric oxide synthase. Circulation 101(23):2742-2748, 2000.

Kerr ME, Marion DW, Sereika SM, Weber BB, Orndoff PA, Henker R, Wilberger J: The effect of cerebrospinal fluid drainage on cerebral perfusion in traumatic brain injured adults: A preliminary report. J Neurosurg Anesthesiol 12(4):324-333, 2000.

Kilpatrick MM, Lowry DW, Firlik AD, Yonas H, Marion DW: Hyperthermia in the neurosurgical intensive care unit. Neurosurg 47(4)850-856, 2000.

Kline AE, Yan HQ, Bao J, Marion DW, Dixon CE: Chronic methylphenidate treatment enhances water maze performance following traumatic brain injury in rats. Neurosci Letters 280(3):163-166, 2000.

Kochanek PM, Clark RSB, Ruppel RA, Adelson PD, Bell MJ, Whalen MJ, Robertson CL, Satchell MA, Seidberg NA, Marion DW, Jenkins LW: Biochemical, cellular and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside. Pediatr Crit Care Med 1(1):4-19, 2000.

Marion DW, Spiegel TP: Changes in the management of severe traumatic brain injury: 1991-1997. Crit Care Med 28(1)16-18, 2000.

Robertson CL, Clark RSB, Dixon CE, Alexander HL, Graham SH, Wisniewski SR, Marion DW, Safar PJ, Kochanek PM: No long term benefit from hypothermia after severe traumatic brain injury with secondary hypoxemia in rats. Crit Care Med 28(9):3218-3223, 2000.

Robertson CL, Hendrich KS, Kochanek PM, Jackson EK, Melick JA, Graham SH, Marion DW, Williams DS, Ho C: Assessment of 2-chloroadenosine treatment after experimental traumatic brain injury in the rat using arterial spin-labeled MRI: A preliminary report. Acta Neurochir Suppl 76:187-189, 2000.

Robertson CL, Minamino N, Ruppel RA, Kangawa K, Adelson PD, Tsuji T, Wisniewski SR, Ohta H, Janesko KL, Kochanek PM: Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in children: A preliminary report. Acta Neurochir Suppl 76:419-421, 2000.

Statler KD, Kochanek PM, Dixon CE, Alexander HL, Warner DS, Clark RSB, Wisniewski SR, Graham SH, Jenkins LW, Marion DW, Safar PJ: Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats. J Neurotrauma 17(12):1179-1189, 2000.

Stevenson KL, Adelson PD. The shaken baby syndrome and non-accidental trauma. Contemporary Neurosurgery 22:4:1-8, 2000.

Tyurin VA, Tyurina YY, Borisenko GG, Sokolova TV, Ritov VB, Quinn PJ, Rose M, Kochanek P, Graham SH, Kagan VE: Oxidative stress following traumatic brain injury in rats: Quantitation of biomarkers and detection of free radical intermediates. J Neurochem 75:2178-2189, 2000.

Virág L, Szabó C: Bcl-2 protects peroxynitrite-treated thymocytes from poly (ADP-ribose) synthase (PARS) independent apoptotic but not from PARS-mediated necrotic cell death, Free Rad Biol Med, 29:704-713, 2000.

Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, Dixon CE, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci 2000;20(18):7037-7042.

Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham S, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM: Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report. Acta Neurochir Suppl. 76:61-4, 2000.

Whalen MJ, Carlos TM, Dixon CE, Robichaud P, Clark RSB, Marion DW, Kochanek PM: Reduced brain edema after traumatic brain injury in mice deficient in p-selectin and intercellular adhesion molecule-1. J Leukocyte Biol 67(2):160-168, 2000.

Whalen MJ, Carlos TM, Kochanek PM, Wisniewski SR, Bell MJ, Clark RSB, DeKosky ST, Marion DW, Adelson PD: Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury. Crit Care Med 28(4):929-934, 2000.

Whalen MJ, Carlos TM, Wisniewski SR, Clark RSB, Melick JA, Marion DW, Kochanek PM: Effect on neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats. Crit Care Med 28(11):3710-3717, 2000.

Witham TF, Thompson TP, Marion DW: Prevention of wound infections in neurosurgery. Contemporary Neurosurg 22(5):1-6,2000.

Woods RJ, Prueckner S, Safar P, Takasu A, Tisherman SA, Jackson EK, Radovsky A, Kochanek PM, Behringer W, Stezoski SW, Hans R: Adenosine by aortic flush fails to augment the brain preservation effect of mild hypothermia during exsanguination cardiac arrest in dogs. An exploratory study. Resuscitation 44:47-59, 2000.

Yan HQ, Yu J, Kline AE, Letart P, Jenkins LW, Marion DW, Dixon CE: Evaluation of combined fibroblast growth factor-2 and moderate hypothermia therapy in traumatically brain injured rats. Brain Res 22;887(1):134-43, 2000.