Baoli Hu, PhD

Assistant Professor


Baoli Hu

Contact

412-692-9457

Biography

Baoli Hu, PhD, joined the faculty of the University of Pittsburgh Department of Neurological Surgery at Children’s Hospital of Pittsburgh of UPMC in July of 2017.

Dr. Hu received his bachelor's and master's degrees from the Northwest A&F University in Xianyang, China in 2001. He earned his PhD degree in microbiology from Wuhan University in Wuhan, Hubei, China in 2004 and completed his postdoctoral training in molecular oncology at H. Lee Moffitt Cancer Center and Research Institute in Tampa, Fla. in 2007.

Prior to joining the faculty at the University of Pittsburgh School of Medicine, Dr. Hu was a senior research scientist in the Department of Genomic Medicine and Cancer Biology at the University of Texas, MD Anderson Cancer Center from 2011-17, working in the lab of Ronald DePinho, MD. From 2007-11 he worked with Dr. DePinho as a research scientist in the Department of Medical Oncology and Belfer Institute for Applied Cancer Science at Dana-Farber Cancer Institute at the Harvard Medical School.

Dr. Hu’s research is focused on understanding the molecular mechanisms of brain tumors evolution in children and adults, including tumor progression and recurrence after the treatment; and developing new strategies for the treatment of these devastating diseases.

Specialized Areas of Interest

Oncobiology of glioma and medulloblastoma; cancer stem cells; functional cancer genomics; mechanisms of tumor initiation, progression, treatment resistance, and recurrence; translational research in druggable targets and biomarkers discovery.

Professional Organization Memberships

American Association for Cancer Research
Society for Neuro-Oncology
Children’s Brain Tumor Tissue Consortium (CBTTC)

Education & Training

BS, Animal Science and Technology, Northwest A&F University, 1998
MS, Animal Breeding and Genetics, Northwest A&F University, 2001 
PhD, Microbiology, Wuhan University, 2004
Postdoctoral Fellow, Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, 2007

Selected Publications

Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell, 10;32(1):42-56, 2017.

Ong DST, Hu B, Ho YW, Sauve, GC, Bristow CA, Wang Q, Multani SA, Chen P, Nezi L, Jiang S, Gorman CE, Monasterio, MM, Koul D, Marchesini M, Colla S, Jin EJ, Sulman EP, Lang FF, Spring DJ, Yung AW, Verhaak RGW, Chin L, Wang YA, and DePinho RA. PAF promotes stemness and radioresistance of glioma stem cells. Proc Natl Acad Sci USA, 114 (43) E9086-9095, 2017.

Shingu T, Ho A, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang, Q, Horner J, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RGW, Heimberger AM, Hu J. QKI deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nature Genetics, 49(1):75-86, 2017.

Hu B, Wang Q, Wang YA, Hua S, Sauve, GC, Ong DS, Zheng, DL, Chang Q, Ho YW, Monasterio, MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao, W, Corley LJ, Yan H, Zhang J, You, Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RGW, DePinho RA. Epigenetic activation of WNT5A drives glioblastoma stem cell differentiation and invasive growth. Cell, 167 (5):1281-1295, 2016.

Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature, 488(7411):337-42, 2012.

Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev, 26(13):1459-72, 2012.

Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci USA, 110(36):14520-7, 2013.

Hu B, Gilkes DM, Chen J. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res, 67(18):8810-7, 2007.

Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J Biol Chem. 2006 281(44):33030-5.

Hu B, Zhu H, Qiu S, Su Y, Ling W, Xiao W, Qi Y. Enhanced TRAIL sensitivity by E1A expression in human cancer and normal cell lines: inhibition by adenovirus E1B19K and E3 proteins. Biochem Biophys Res Commun, 325(4):1153-62, 2004.

A complete list of Dr. Hu's publications can be reviewed through the National Library of Medicine's publication database.