David O. Okonkwo, MD, PhDProfessor of Neurological Surgery
Clinical Director, Brain Trauma Research Center
Executive Vice Chairman, Clinical Operations
Director, Neurotrauma Program
Director, Scoliosis and Spinal Deformity Program
David O. Okonkwo, MD, PhD, is executive vice chair for clinical operations and is director of neurotrauma, director of scoliosis and spinal deformity at UPMC Presbyterian. He is also associate professor and clinical director of the Brain Trauma Research Center of the University of Pittsburgh.
Dr. Okonkwo completed his undergraduate work at the University of Virginia, where he received the University Academic Achievement Award and was named a Howard Hughes Undergraduate Biomedical Research Scholar. He completed his medical and doctoral education through the MD/PhD program of the Medical College of Virginia of Virginia Commonwealth University.
He joined the University of Pittsburgh Department of Neurological Surgery in 2006 following completion of neurosurgical residency at the University of Virginia and a fellowship at Auckland Public Hospital, Auckland, New Zealand. He has additional specialized training in scoliosis and other spinal deformities.
Dr. Okonkwo’s clinical interests are traumatic injuries to the brain and spine as well as scoliosis and spinal deformity. His research endeavors involve developing novel therapeutic interventions for brain and spinal cord injury. Dr. Okonkwo is the principal investigator of a nationally funded clinical core to study the pathophysiology of traumatic brain injury. He is also principal investigator of several ongoing clinical studies in neurotrauma in Pittsburgh.
Dr. Okonkwo has published more than 90 papers in refereed journals, authored numerous book chapters, and garnered several awards for his scientific research. He is a member of the American Association of Neurological Surgeons, the Congress of Neurological Surgeons and the National and International Neurotrauma Societies.
Dr. Okonkwo's publications can be reviewed through the National Library of Medicine's publication database.
Specialized Areas of Interest
Brain and spine trauma; scoliosis; spinal deformity; minimally invasive spine surgery; experimental therapies for brain and spinal cord injuries
American Board of Neurological Surgery
Children's Hospital of Pittsburgh of UPMC
Magee-Womens Hospital of UPMC
Veterans Affairs Pittsburgh Healthcare System
Professional Organizational Membership
Alpha Omega Alpha Medical Honor Society
American Association of Neurological Surgeons
American College of Surgeons (Associate Member)
American Spinal Injury Association
Congress of Neurological Surgeons
International Neurotrauma Society
National Neurotrauma Society
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March 2, 2012
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March 1, 2012
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August 23, 2011
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1) Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI)
TRACK-TBI is an 11-site consortium that is recruiting 3,000 acute TBI subjects. TRACK-TBI will directly impact the public health by creating an open-access Information Commons of integrated clinical, imaging, proteomic, genomic, and outcome biomarkers, that will permit more precise TBI diagnosis, prognosis, and treatment. Dr. Okonkwo is principal investigator of the clinical core.
2)Targeted Evaluation, Action, and Monitoring of Traumatic Brain Injury (TEAM-TBI)
TEAM-TBI is a monitored multiple intervention clinical trial for TBI patients designed to address the heterogeneity of TBI and identify evidence-based therapies for participating subjects. In TEAM-TBI, small groups of TBI patients undergo a comprehensive intake evaluation, complemented by advanced neuroimaging, biomarker analysis and an innovative sleep study analysis. A multi-disciplinary panel reviews all data, stratifies subjects into clinical TBI subtypes (trajectories) and recommends targeted therapeutic interventions. Each participant departs Pittsburgh with a customized TEAM-TBI toolkit containing necessary materials for targeted therapies.
3) In Vivo Neuroimaging Biomarker Panel for Chronic Traumatic Encephalopathy
This project develops and tests an in vivo neuroimaging biomarker panel for chronic traumatic encephalopathy, consisting of use high-resolution positron emission tomography (PET) imaging combined with white matter damage using MR-based High Definition Fiber Tracking (HDFT) and cerebrospinal fluid analyses for detecting pathological changes in total tau, phosphorylated tau, and Aβ peptides. The goal is to provide quantitative early non-invasive assessment of CTE disease to identify targets for CTE therapy.
4) High Definition Fiber Tracking Biological Diagnosis of TBI Providing Actionable Clinical Report of Quantified Damage
The goal of this project is to test and deploy a technology that will provide a biological diagnosis of acute traumatic brain injury (TBI) based on a new MRI diffusion method called High Definition Fiber Tracking (HDFT).