David O. Okonkwo, MD, PhDProfessor
Executive Vice Chair, Clinical Operations
Clinical Director, Brain Trauma Research Center
David O. Okonkwo, MD, PhD, is executive vice chair for clinical operations and is director of neurotrauma, director of scoliosis and spinal deformity at UPMC Presbyterian. He is also professor and clinical director of the Brain Trauma Research Center of the University of Pittsburgh.
Dr. Okonkwo completed his undergraduate work at the University of Virginia, where he received the University Academic Achievement Award and was named a Howard Hughes Undergraduate Biomedical Research Scholar. He completed his medical and doctoral education through the MD/PhD program of the Medical College of Virginia of Virginia Commonwealth University.
He joined the University of Pittsburgh Department of Neurological Surgery in 2006 following completion of neurosurgical residency at the University of Virginia and a fellowship at Auckland Public Hospital, Auckland, New Zealand. He has additional specialized training in scoliosis and other spinal deformities.
Dr. Okonkwo’s clinical interests are traumatic injuries to the brain and spine as well as scoliosis and spinal deformity. His research endeavors involve developing advanced neuroimaging modalities and novel therapeutic interventions for brain and spinal cord injury. Dr. Okonkwo is the principal investigator of a nationally funded clinical core to study the pathophysiology of traumatic brain injury. He is also principal investigator of several ongoing clinical studies in neurotrauma in Pittsburgh.
Dr. Okonkwo has published more than 120 papers in refereed journals, authored numerous book chapters, and garnered several awards for his scientific research. He is a member of the American Association of Neurological Surgeons, the Congress of Neurological Surgeons and the National and International Neurotrauma Societies.
Specialized Areas of Interest
Brain and spine trauma; scoliosis; spinal deformity; minimally invasive spine surgery; experimental therapies for brain and spinal cord injuries.
American Board of Neurological Surgery
Children's Hospital of Pittsburgh of UPMC
Magee-Womens Hospital of UPMC
Veterans Affairs Pittsburgh Healthcare System
Professional Organizational Membership
Alpha Omega Alpha Medical Honor Society
American Association of Neurological Surgeons
American Spinal Injury Association
Congress of Neurological Surgeons
National Neurotrauma Society
Education & Training
BA, Biology, University of Virginia, 1994
MD, Virginia Commonwealth University, 2000
PhD, Anatomy, Virginia Commonwealth University, 2000
Fellowship, Neurosurgery, Auckland Public Hospital, 2005
Residency, Neurosurgery, University of Virginia, 2006
Honors & Awards
Best Doctors in America, 2012-15
Pittsburgh’s Best Doctors, Pittsburgh Magazine, 2012-15
Hamilton DK, Kanter AS, Bolinger BD, Mundis GM Jr, Nguyen S, Mummaneni PV, Anand N, Fessler RG, Passias PG, Park P, La Marca F, Uribe JS, Wang MY, Akbarnia BA, Shaffrey CI, Okonkwo DO; International Spine Study Group (ISSG). Reoperation rates in minimally invasive, hybrid and open surgical treatment for adult spinal deformity with minimum 2-year follow-up. Eur Spine J [Epub ahead of print], 2016.
Park P, Okonkwo DO, Nguyen S, Mundis GM Jr, Than KD, Deviren V, La Marca F, Fu KM, Wang MY, Uribe JS, Anand N, Fessler R, Nunley PD, Chou D, Kanter AS, Shaffrey CI, Akbarnia BA, Passias PG, Eastlack RK, Mummaneni PV; International Spine Study Group. Can a Minimal Clinically Important Difference Be Achieved in Elderly Patients With Adult Spinal Deformity Who Undergo Minimally Invasive Spinal Surgery? World Neurosurg 86:168-72, 2016.
Wang KK, Yang Z, Yue JK, Zhang Z, Winkler EA, Puccio A, Diaz-Arrastia R, Lingsma H, Yuh EL, Mukherjee P, Valadka A, Gordon WA, Okonkwo DO, Manley GT. Plasma Anti-Glial Fibrillary Acidic Protein (GFAP) Autoantibody Levels During the Acute and Chronic Phases of Traumatic Brain Injury - A TRACK-TBI Pilot Study. J Neurotrauma [Epub ahead of print], 2016.
Presson N, Beers SR, Morrow L, Wagener LM, Bird WA, Van Eaman G, Krishnaswamy D, Penderville J, Borasso A, Benso S, Puccio AM, Fissel C, Okonkwo DO, Schneider W. An exploratory analysis linking neuropsychological testing to quantification of tractography using High Definition Fiber Tracking (HDFT) in military TBI. Brain Imaging Behav 9(3):484-99, 2015
Korley FK, Diaz-Arrastia R, Wu AH, Yue JK, Manley GT M D Ph D, Sair HI, Van Eyk J, Everett AD, Okonkwo DO, Valadka A, Gordon WA, Maas A, Mukherjee P, Yuh EL, Lingsma H, Puccio AM, Schnyer DM. Circulating Brain Derived Neurotrophic Factor (BDNF) Has Diagnostic and Prognostic Value in Traumatic Brain Injury. J Neurotrauma 33(2): 215-25, 2015.
Presson N, Krishnaswamy D, Wagener L, Bird W, Jarbo K, Pathak S, Puccio AM, Borasso A, Benso S, Okonkwo DO, Schneider W. Quantifying white matter structural integrity with high-definition fiber tracking in traumatic brain injury. Mil Med 180(3 Suppl):109-21, 2015.
Park P, Wang MY, Lafage V, Nguyen S, Ziewacz J, Okonkwo DO, Uribe JS, Eastlack RK, Anand N, Haque R, Fessler RG, Kanter AS, Deviren V, La Marca F, Smith JS, Shaffrey CI, Mundis GM Jr, Mummaneni PV, on behalf of the International Spine Study Group. Comparison of two minimally invasive surgery strategies to treat adult spinal deformity. J Neurosurg Spine 22(4):374-80, 2015.
Diaz-Arrastia R, Wang KK, Papa L, Sorani MD, Yue JK, Puccio AM, McMahon PJ, Inoue T, Yuh EL, Lingsma HF, Maas AIR, Valadka AB, Okonkwo DO, Manley GT and the TRACK-TBI Investigators. Acute biomarkers of traumatic brain injury: Relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP). J Neurotrauma 31(1):19-25, 2014.
Okonkwo DO, Yue JK, Puccio AM, Panczykowski DM, Inoue T, McMahon PJ, Sorani MD, Yuh EL, Lingsma HL, Maas AIR, Valadka AB, Manley GT, and TRACK-TBI Investigators. GFAP-BDP as an Acute Diagnostic Marker in Traumatic Brain Injury: Results from the prospective TRACK-TBI Study. J Neurotrauma 30(17):1490-7, 2013.
Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, Janis LS, Wilde E, Taylor P, Harshman K, Conley A, Puccio A, Levin HS, McCauley SR, Bucholz RD, Smith KR, Schmidt JH, Scott JN, Yonas H, Okonkwo DO. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol 10(2):131-9, 2011.
A complete list of Dr. Okonkwo's publications can be reviewed through the National Library of Medicine's publication database.
1) Transforming Research and Clinical Knowledge in Traumatic Brain Injury (aka TRACK-TBI)
TRACK-TBI is an 11-site consortium that is recruiting 3000 acute TBI subjects. TRACK-TBI will directly impact the public health by creating an open-access Information Commons of integrated clinical, imaging, proteomic, genomic, and outcome biomarkers, that will permit more precise TBI diagnosis, prognosis, and treatment. Dr. Okonkwo is Principal Investigator of the Clinical Core.
2) Targeted Evaluation, Action, and Monitoring of Traumatic Brain Injury (aka TEAM-TBI)
TEAM-TBI is a monitored multiple intervention clinical trial for TBI patients designed to address the heterogeneity of TBI and identify evidence-based therapies for participating subjects. In TEAM-TBI, small groups of TBI patients undergo a comprehensive intake evaluation, complemented by advanced neuroimaging, biomarker analysis and an innovative sleep study analysis. A multi-disciplinary panel reviews all data, stratifies subjects into clinical TBI subtypes (trajectories) and recommends targeted therapeutic interventions. Each participant departs Pittsburgh with a customized TEAM-TBI Toolkit containing necessary materials for targeted therapies.
3) In Vivo Neuroimaging Biomarker Panel for Chronic Traumatic Encephalopathy
This project develops and tests an in vivo neuroimaging biomarker panel for chronic traumatic encephalopathy, consisting of use high-resolution positron emission tomography (PET) imaging combined with white matter damage using MR-based High Definition Fiber Tracking (HDFT) and cerebrospinal fluid analyses for detecting pathological changes in total tau, phosphorylated tau, and Aβ peptides. The goal is to provide quantitative early non-invasive assessment of CTE disease to identify targets for CTE therapy.
4) High Definition Fiber Tracking Biological Diagnosis of TBI Providing Actionable Clinical Report of Quantified Damage
The goal of this project is to test and deploy a technology that will provide a biological diagnosis of acute traumatic brain injury (TBI) based on a new MRI diffusion method called High Definition Fiber Tracking (HDFT).
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