Fang-Cheng Yeh, MD, PhD

Fang-Cheng (Frank) Yeh, MD, PhD, joined the Department of Neurological Surgery in 2016 after receiving his MD from National Taiwan University and completing his PhD in biomedical engineering at Carnegie Mellon University. His research focuses on diffusion MRI and tractography-based connectomics, with contributions that have shaped the study of brain connectivity in both research and clinical contexts.

Dr. Yeh is the developer of DSI Studio, an open-source software widely used in the neuroscience community for diffusion MRI analysis. The software provides tools for image preprocessing, tensor estimation, and fiber tracking, along with features such as quality control, ROI editing, and clustering analysis. Its support for various diffusion MRI data types has made it compatible with a broad range of studies. DSI Studio has been cited in over 2,000 peer-reviewed publications and continues to evolve with regular updates, including GPU acceleration and cloud-based processing to handle larger datasets.

Dr. Yeh also introduced two analytic frameworks: correlational tractography and differential tractography. Correlational tractography enables the identification of white matter pathways associated with specific clinical or cognitive variables, offering insights into how brain connectivity relates to behavior and disease. Differential tractography, on the other hand, detects longitudinal changes in neural pathways, facilitating the study of disease progression and neuroplasticity. Together, these tools and methods support a growing number of studies in connectomics and provide the research community with practical resources to investigate brain structure and function across a variety of neurological conditions.

Dr. Yeh's publications can be reviewed through the National Library of Medicine's publication database.