Robert M. Friedlander, MD, MA

Chair, Walter E. Dandy Professor
Head of Cerebrovascular Neurosurgery


Robert Friedlander

Contact

412-647-6358

Biography

On June 1, 2010, Robert Friedlander, MD, MA, became the fourth chair in the department’s history. Prior to joining the department, Dr. Friedlander was professor of neurosurgery at Harvard Medical School and vice-chairman of neurosurgery and associate director of cerebrovascular surgery at Brigham and Women’s Hospital in Boston.

As a sign of his prominence as a clinician and scientist, Dr. Friedlander is one of a very select group of authors to have been invited by the New England Journal of Medicine to write both a basic science review (mechanisms of neuronal cell death), as well as a clinical review (management of AVMs). Clinically, Dr. Friedlander focuses on the operative management of complex cerebrovascular disorders and brain tumors.

Dr. Friedlander’s major research interests lie in the study of the mechanistic pathways of the caspase apoptosis gene family. As co-director of Brigham and Women’s Neuroscience Research Center, his work includes the evaluation of treatment strategies for neurodegenerative diseases (Huntington’s and ALS), stroke, brain trauma, and spinal cord injury through the modulation of the caspase-family apoptotic pathways.

Dr. Friedlander’s research has received significant media attention including major work published in Nature, Science, and Nature Medicine.

His work has also been recognized through many academic awards, including the Neurosurgery Resident Award from the Congress of Neurological Surgeons, the Bayer Cerebrovascular Award from the Joint Section of Cerebrovascular Surgery, the International Charcot Prize for Motor Neuron Diseases, and the Award from the Academy of Neurological Surgeons. In 2006, he was elected as a member of the prestigious American Society for Clinical Investigation. Dr. Friedlander is only one of two neurosurgeons elected as a member of the American Association of Physicians.

Specialized Areas of Interest

Aneurysms, vascular malformations, brain tumors, carotid disease, cerebrovascular disease, Chiari malformation, spinal cord tumors. Research focuses on mechanisms of apoptosis, Huntington’s disease, ALS, and stroke.

Board Certifications

American Board of Neurological Surgeons

Hospital Privileges

Children’s Hospital of Pittsburgh of UPMC
UPMC Mercy
UPMC Passavant
UPMC Presbyterian
UPMC Shadyside

Professional Organization Membership

American Academy of Neurological Surgeons
American Association for the Advancement of Science
American Association of Neurological Surgeons
American Association of Physicians
American Society for Clinical Investigation
Brain Aneurysm Foundation, Medical Advisory Board
Congress of Neurological Surgeons
Joint Section of Cerebrovascular Surgery
Sociedad Venezolana de Neurocirugia 
Society for Neurological Surgeons
Society for Neuroscience

Education & Training

BA, Brandeis University, 1987
MA, Biochemistry, Brandeis University, 1987
MD, Harvard Medical School, 1991

Honors & Awards

  • Best Doctors in America, 2012-2015
  • America’s Top Surgeons, 2013
  • H. Richard Winn Prize for Neurosurgical Research
  • Castle Connolly Top Doctor in the Field of Neurological Surgery, 2013
  • Honored Guest, US Ambassador, Belgrade, Serbia, 2013
  • Honored Guest, HRH Crown Prince Alexander and HRH Crown Princess Katherine, Belgrade, Serbia, 2014

Selected Publications

Isolation of functionally active and highly purified neuronal mitochondria from Human Cortex. Khattar NK, Yablonska S, Baranov SV, Baranova OV, Kretz ES, Larkin TM, Carlisle DL, Richardson RM, Friedlander RM. J Neurosci Methods [Epub ahead of print], 2016.

Kozai TD, Du Z, Gugel ZV, Smith MA, Chase SM, Bodily LM, Caparosa EM, Friedlander RM, Cui XT. Comprehensive chronic laminar single-unit, multi-unit, and local field potential recording performance with planar single shank electrode arrays. J Neurosci Methods 242:15-40, 2015.

Kagan VE, Tyurina YY, Tyurin VA, Mohammadyani D, Angeli JP, Baranov SV, Klein-Seetharaman J, Friedlander RM, Mallampalli RK, Conrad M. Bayir H.  Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation. Antioxid Redox Signal 22(18):1667-80, 2015.

Sirianni AC, Jiang J, Zeng J, Mao LL, Zhou S, Sugarbaker P, Zhang X, Li W, Friedlander RM, Wang X. N-acetyl-L-tryptophan, but not N-acetyl-D-tryptophan, Rescues neuronal CellDeath in Models of Amyotrophic Lateral Sclerosis. J Neurochem [Epub ahead of print], 2015

Faraji AH, Abhinav K, Jarbo K, Yeh FC, Shin SS, Pathak S, Hirsch BE, Schneider W, Fernandez-Miranda JC, Friedlander RM. Longitudinal evaluation of corticospinal tract in patients with resected brainstem cavernous malformations using high-definition fiber tractography and diffusion connectometry analysis: preliminary experience. J Neurosurg 2015 Jun 5:1-12, 2015.

Shin SS, Murdoch G, Hamilton RL, Faraji AH, Kano H, Zwagerman NT, Gardner PA, Lunsford LD, Friedlander RM. Pathological response of cavernous malformations following radiosurgery. J Neurosurg 19:1-7, 2015.

Agarwal N, Shah K, Stone JG, Ricks CB, Friedlander RM.  Educational Resources “Over the Head” of Neurosurgical Patients:  The Economic Impact of Inadequate Health Literacy. World Neurosurg S1878-8750(15), 2015.

Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury.  Du R, Zhou J, Lorenzano S, Liu W, Charoenvimolphan N, Qian B, Xu J, Wang J, Zhang X, Wang X, Berndt A, Devan WJ, Valant VJ, Wang J, Furie KL, Rosand J, Rost N, Friedlander RM, Paigen B, Weiss ST. Stroke 46(12):3514-22, 2015.

Bulara KR, Gunel M, Amin-Hanjani S, Chen PR, Connolly ES, Friedlander RM. Results of a national cerebrovascular neurosurgery survey on the management of cerebral vasospasm/delayed cerebral ischemia. J Neurointerv Surg [Epub ahead of print], 2014.

Raji CA, Eyre H. Wei SH, Bredesen DE, Moylan S, Law M, SmallG, Thompson PM, Friedlander RM, Silverman DH, Baune BT, Hoang TA, Salamon T, Toga AW, Vernooij MW. Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline.  AJNR Am J Neuroradiol [Epub ahead of print], 2014.

A complete list of Dr. Friedlander's publications can be reviewed through the National Library of Medicine's publication database.

Research Activities

The focus of Dr. Friedlander’s laboratory is the study of the basic mechanisms of apoptosis, as mediated by the caspase apoptotic family in neurological diseases. In addition, discovering novel approaches to ameliorate the impact of cell death in a variety of neurological diseases is a central theme of the Neuroapoptosis Laboratory. 

1) Researchers in Dr. Friedlander’s lab are evaluating the impact apoptotic cell death, and in particular, that mediated by the caspase cell death family on the pathogenesis of neurodegenerative diseases. Neurodegenerative diseases presently being investigated are amyotrophic lateral sclerosis (ALS) as well as Huntington’s Disease (HD). Activation of the caspase cell death cascade appears to play an important role in a variety of neurodegenerative diseases. Researchers have demonstrated that inhibition of the caspase-1 (also known as ICE) apoptotic protein slows the progression and delays mortality in transgenic mouse models of ALS and Huntington’s disease. Furthermore, delivering caspase inhibitors directly in to the brain of these transgenic mice prolongs their survival. This was the first time that any intervention had been demonstrated efficacious in an ALS or HD model. Adding relevancy to these findings, researchers have also demonstrated that caspase-1 is activated in the brain and spinal cord of humans with HD and ALS respectively. Researchers have also demonstrated that minocycline demonstrates neuroprotection in a mouse model of HD.

2) Apoptotic cell death plays a significant role in stroke as well as traumatic brain and spinal cord injury. Researchers in Dr. Friedlander’s lab are evaluating the impact caspase activation has on apoptotic cell death in these conditions. The relation of the caspase family and free radical production is also being investigated. Targeted caspase-mediated pharmacoprotection is also being investigated.

3) Using in vitro models, researchers are evaluating both the mechanisms involved in the activation of ICE, as well as the post-ICE activation pathways involved cell death. The role of Interleukin-1β in apoptosis continues to be a focus of research. Researchers are also continuing to evaluate the basic mechanisms of cell death, and especially as they relate to neurologic diseases.

Media Appearances

UPMC-Developed Fiber Tracking Technology Being Called Life-Changing For Cancer Patients
September 8, 2016
KDKA-TV Evening News

Crown prince of Serbia seeks Pittsburgh medical expertise for his homeland
April 26, 2015
Pittsburgh Post-Gazette

Crown Prince Alexander and Crown Princess Katherine at a Charity Dinner in Pittsburgh
April 25, 2015
royalfamily.org

Neurosurgical treatments give patients chance at pain-free lives
February 7, 2015
Pittsburgh Tribune-Review

Hospitals bank on neurosurgery procedures to boost bottom line
February 7, 2015
Pittsburgh Tribune-Review

Talented woodworker survives brain cancer after delicate surgery
December 24, 2014
WTAE-TV 4 Pittsburgh

Bride Walks Down the Aisle
October 7, 2014
WTAE-TV 4 
Pittsburgh

Friedlander Discusses Brain Aneurysms
August 20, 2014
KDKA Radio Morning News

Why Major League Pitchers Won’t Wear This Weird Hat
July 24, 2014
New York Times Magazine

Surgery can fix brain aneurysm; support can help recovery
July 7, 2014
Pittsburgh Post-Gazette

New Study Supports Conservative Management Over Intervention for Unruptured Brain AVMs
June 5, 2014
Neurology Today

Study shows for first time how Huntington's disease protein could cause death of neurons
May 19, 2014
Medical Xpress

Pitt Study Shows How Huntington’s Disease Protein Could Cause Death of Neurons
May 19, 2014
Gant Daily

Former college football player, city firefighter sues NCAA over concussions
December 17, 2013
Pittsburgh Tribune-Review

Ex-player sues NCAA over football injuries
December 17, 2013
Pittsburgh Post-Gazette

Foundations give Pitt $100,000 for ALS research
October 7, 2013
Pittsburgh
 Post-Gazette

Pitt findings on Lou Gehrig's disease may hold hope
April 26, 2013
Pittsburgh Post-Gazette

Melatonin Delays ALS Symptom Onset and Death in Mice
April 25, 2013
Science Daily

Cerebral Aneurysms: Analyzing the Treatment Shift
February 13, 2013
Physician's Weekly

Melatonin Delays Onset, Reduces Deaths in Mouse Model of Huntington’s Disease
October 11, 2011
Science Daily

Rep. Giffords has surgery to repair skull
May 19, 2011
Washington Times (Associated Press)

Caspases—Guilty of Murder in First, and Now Second Degrees
March 12, 2011
Altzheimer Research Forum

UPMC Doctor Discusses Prognosis For Rep. Gabrielle Giffords
January 10, 2011
WTAE-TV (Pittsburgh) Action News

Blocking Apoptosis Delays ALS in Mice
October 15, 2010
Altzheimer Research Forum

The lasting impact of concussions
August 18, 2010
Yahoo! Sports

What caused the woman's headache and paralysis?
July 13, 2004
Boston Globe

Newsmaker: Dr. Robert Friedlander
June 17, 2010
Pittsburgh Tribune-Review

Antibiotic May Slow Gehrig's Disease
May 6, 2002
Associated Press 

An Old Antibiotic Generates New Hopes
July 11, 2000
New York Times

Minocycline slows progress of Huntington's disease in mice
July 8, 2000
British Medical Journal

Antibiotic may help fight Huntington's
June 27, 2000
USA Today

Brain drug shows promise: Slows ALS, may treat other diseases
April 14, 2000
Boston Herald

Lou Gehrig's disease slowed in mice
April 14, 2000
Boston Globe (Associated Press)

Way To Delay Huntington's Disease Found
June 19, 1999
Harvard University Gazette

Scientists slow progress of Huntington's in mice
May 20, 1999
CNN.com

Hope in Brain-Disorder Fight/Tests yield Huntington's clues
May 20, 1999
Newsday

Approach may slow Huntington’s
May 19, 1999
MSNBC.com

Scientists slow progress of Huntington's in mice
May 19, 1999
ABC News

Study Targets Huntington's Key
May 19, 1999
CBS News 

UPMC OnTopic Discussions

Carotid Stenosis
Dr. Friedlander discusses the diagnosis and treatment of carotid stenosis. (ver en Español)

Chiari Malformation
Dr. Friedlander discusses the diagnosis and treatment of Chiari Malformations. (ver en Español)

Trabajo en Equipo
Dr. Friedlander discute el enfoque del trabajo en equipo para el tratamiento de pacientes neuroquirúrgicos en UPMC.

Aneurismas
Dr. Friedlander analiza las opciones de tratamiento de los aneurismas no rotos en UPMC.

Neurosurgery at UPMC: A powerful team approach
Dr. Friedlander discusses the power of a team approach to treating neurosurgical patients at UPMC.