Georgios Zenonos, MD

  • Assistant Professor
  • Associate Director, Center for Cranial Base Surgery

Georgios A. Zenonos, MD, joined the University of Pittsburgh Department of Neurological Surgery as associate director of Center for Cranial Base Surgery in July of 2019 after having received extensive formal sub-specialization in the field. He is one of a handful of neurosurgeons to have completed two fellowships in skull base surgery, one focusing on endoscopic and minimally invasive approaches at the University of Pittsburgh, and another focusing on complex cranial neurosurgery and cerebrovascular neurosurgery at the University of Miami with the renown Jacques J. Morcos, MD, and Roberto C. Heros, MD.

Dr. Zenonos completed his internship, residency and chief residency in neurosurgery at the University of Pittsburgh from 2011-18. During this time, he received several distinctions and awards, including an award for achieving the highest score in the nation on the American Board of Neurological Surgery written exam. Other awards include the Robert J. Dempsey Award by the CNS/AANS Joint Cerebrovascular Section, the University of Pittsburgh Stuart N. Rowe Research Award, first place in the North American Skull Base Society knowledge competition, and four Walter L. Copeland Awards for cranial research. In addition, Dr. Zenonos has published extensively (see Google Scholar and PubMed), has given numerous presentations nationally and internationally, and has been frequently invited as a scientific reviewer by prominent neurosurgical journals.

Before residency, Dr. Zenonos, a native of Greece, graduated as valedictorian from the University of Athens School of Medicine in Greece, which he attended with a scholarship from the Ministry of Education. Winning the Alexander S. Onassis Award, he then pursued a basic science post-doctoral research fellowship at Harvard Medical School to study the mechanisms of programmed cell death.

“I understand that having to see a neurosurgeon, or needing a neurosurgical procedure has to be one of the most frightening experiences in someone’s life,” Dr. Zenonos says. “My goal is to always to provide the best care possible for each and every one of my patients, one that utilizes the latest technologies and techniques, and one that is founded by evidence-based medicine – the same care I would want for my family, my friends, or myself. Putting myself in the patient’s shoes, and understanding the unique difficulties they are facing is always step one.”

Dr. Zenonos’ research interests include genetics of skull base tumors; surgical anatomy (refinement of skull base approaches, and surgical technique); skull base outcomes research; and high-definition fiber tactography

Specialized Areas of Interest

Endoscopic endonasal neurosurgery; minimally invasive neurosurgery; skull base tumors; skull base pathology; neuro-oncology; cerebrovascular neurosurgery; cranial nerve disorders; radiosurgery.

Board Certifications

American Board of Neurological Surgeon

Hospital Privileges

UPMC Altoona
UPMC Children’s Hospital of Pittsburgh
UPMC Hamot
UPMC Mercy
UPMC Presbyterian
UPMC Shadyside

Professional Organization Membership

American Association of Neurological Surgeons
American Medical Association
Congress of Neurological Surgeons
North American Skull Base Society
Alexander S. Onassis Scholars Society

Education & Training

  • MD, National & Kapodistrian University of Athens School of Medicine, 2002-08
  • Post-Doctoral Research Fellowship, Harvard Medical School, 2009-10
  • Residency, neurological surgery, UPMC, 2011-18
  • Fellowship, Minimally Invasive, and Open Skull Base Neurosurgery, University of Pittsburgh, 2015-17
  • Fellowship, Complex Skull Base and Cerebrovascular Neurosurgery, University of Miami, 2019

Honors & Awards

  • Best Basic Science Abstract, NASBS meeting, 2021 (senior author)
  • Best Neurosurgical Fellow Teacher Award, University of Miami, 2019
  • First Place, North American Skull Base Society Jeopardy Knowledge Competition, 2018
  • p clinical abstract presentation shortlist, North American Skull Base Society Annual Meeting, 2018
  • The Walter L. Copeland Award for Cranial Research, 2012-13, 2015, 2017
  • Runner-Up Presentation Award, Stuart N. Rowe Society Lectureship, 2017
  • Best Presentation Award, Stuart Rowe Society Lectureship, 2016
  • Award for achieving the highest score in the nation, ABNS Primary Examination, 2016
  • Chordoma Foundation Travel Scholarship, 2016
  • Robert J. Dempsey Joint AANS/CNS Cerebrovascular Section Award, 2015
  • 3rd Best Abstract – Stereotactic and Functional Section, American Association of Neurological Surgery Annual Scientific Meeting, 2014
  • Alexander S. Onassis Award, 2010
  • Valedictorian, National and Kapodistrian University of Athens, School of Medicine, 2008
  • National Scholarship Foundation Award: 2003-08
  • Baronos Award for Excellence in Pharmacology, 2005
  • Ministry of Education Scholarship, 2002-08
  • First ranking graduate, Military Officer Academy, 2001
  • National Physics Olympiad Prize, 2000

Selected Publications

Zenonos GA, Morcos JJ. Occipital to Angular Artery Bypass for Post-irradiation Ischemia: 3-Dimensional Operative Video. Oper Neurosurg (Hagerstown) [Epub ahead of print], 2019.

Caparosa EM, Sedgewick AJ, Zenonos G, Zhao Y, Carlisle DL, Stefaneanu L, Jankowitz BT, Gardner P, Chang YF, Lariviere WR, LaFramboise WA, Benos PV, Friedlander RM. Regional Molecular Signature of the Symptomatic Atherosclerotic Carotid Plaque. Neurosurgery [Epub ahead of print], 2018.

Zenonos GA, Fernandez-Miranda JC, Mukherjee D, Chang YF, Panayidou K, Snyderman CH, Wang EW, Seethala RR, Gardner PA. Prospective validation of a molecular prognostication panel for clival chordoma. J Neurosurg [Epub ahead of print], 2018.

Zenonos GA, Wang EW, Fernandez-Miranda JC. Infrasellar Endoscopic Endonasal Approach for a Pituitary Adenoma Extending into the Third Ventricle, with Anterior Displacement of the Pituitary Gland. J Neurol Surg B Skull Base 79(Suppl 2):S233-S234, 2018.

Ferrareze Nunes C, Lieber S, Truong HQ, Zenonos G, Wang EW, Snyderman CH, Gardner PA, Fernandez-Miranda JC. Endoscopic endonasal transoculomotor triangle approach for adenomas invading the parapeduncular space: surgical anatomy, technical nuances, and case series. J Neurosurg [Epub ahead of print], 2018.

Zenonos GA, Wang EW, Fernandez-Miranda JC. Endoscopic Endonasal Transoculomotor Triangle Approach for the Resection of a Pituitary Adenoma with Ambient Cistern Extension. J Neurol Surg B Skull Base 79(Suppl 3):S283, 2018.

Geltzeiler M, Nakassa ACI, Turner M, Setty P, Zenonos G, Hebert A, Wang E, Fernandez-Miranda J, Snyderman C, Gardner P. Evaluation of Intranasal Flap Perfusion by Intraoperative Indocyanine Green Fluorescence AngiographyOper Neurosurg (Hagerstown) 15(6):672-676, 2018. 

Mehta GU, Zenonos G, Patibandla MR, Lin CJ, Wolf A, Grills I, Mathieu D, McShane B, Lee JY, Blas K, Kondziolka D, Lee CC, Lunsford LD, Sheehan JP. Outcomes of stereotactic radiosurgery for foramen magnum meningiomas: an international multicenter study. J Neurosurg 129(2):383-389, 2018.

Zenonos GA, Fernandes-Cabral D, Nunez M, Lieber S, Fernandez-Miranda JC, Friedlander RM. The epitrigeminal approach to the brainstem. J Neurosurg 128(5):1512-1521, 2018.

Zwagerman NT, Zenonos G, Lieber S, Wang WH, Wang EW, Fernandez-Miranda JC, Snyderman CH, Gardner PA. Endoscopic transnasal skull base surgery: pushing the boundaries. J Neurooncol 130(2):319-330, 2016.