The University of Pittsburgh Department of Neurological Surgery operates a number of specialized research laboratories, each focusing on a unique area. These laboratories include:
Brain Tumor Biology and Therapy Laboratory
The Brain Tumor Biology and Therapy Laboratory, under the direction of Sameer Agnihotri, PhD, studies pediatric and adult high-grade gliomas (HGG) and diffuse intrinsic pontine gliomas (DIPG).
Brain Tumor Evolution & Therapy Laboratory
The Laboratory of Brain Tumor Evolution & Therapy, under the direction of Baoli Hu, PhD, studies the genetic and epigenetic events contributing to the evolution of brain tumors.
Brain Tumor Nanotechnology Laboratory
UPMC Hillman Cancer Center lab directed by Costas G. Hadjipanayis, MD, PhD, involved in the testing of nanoparticle constructs for the targeted imaging and therapy of patient-based brain tumor models.
Cerebral Aneurysm Research Laboratory
The Cerebral Aneurysm Research Lab, led by resident Kamil W. Nowicki, MD, PhD, studies the molecular pathways underlying cerebral aneurysm formation in order to induce repair and prevent rupture.
Clinical Neurophysiology Laboratory
The Clinical Neurophysiology Laboratory, led by Parthasarathy Thirumala, MD, MS, studies the diagnostic value of intraoperative neuromonitoring (IONM) during surgery to detect perioperative neurological disorders.
Cognitive Neurodynamics Laboratory
The Laboratory of Cognitive Neurodynamics, under the direction of Avniel Ghuman, PhD, studies how our brain turns what falls upon our eyes into the rich meaningful experience that we perceive in the world around us.
Cortical Systems Laboratory
Neuroscience lab, under the direction of Jorge Gonzalez-Martinez, studying brain electrophysiology and behavior in patients undergoing epilepsy and movement disorder surgery.
Fiber Tractography Lab
The Fiber Tractography Lab—under the direction of Frank Yeh, PhD—is focused on the application of High-Definition Fiber Tractography for presurgical planning and intraoperative navigation to facilitate brain function preservation.
Molecular Tumor Personalized Precision Lab
The Molecular Tumor Biology and Personalized Precision Therapy Lab, directed by Pascal Zinn, focuses on personalized patient-centered care for brain and spinal tumors
The Neuroapoptosis Laboratory, under the direction of Robert Friedlander, MD, studies the basic mechanisms of apoptosis, as mediated by the caspase apoptotic family in neurologic diseases.
Pediatric Neurosurgery ImmunoOncology Laboratory
The Pediatric Neurosurgery ImmunoOncology Laboratory (PNIO), under the direction of Gary Kohanbash, PhD, seeks to develop novel immuno-oncology approaches to treat deadly pediatric central nervous system tumors.
Spinal Cord Stimulation Lab
The Spinal Cord Stimulation Laboratory, under the direction of Marco Capogrosso, PhD, studies the interactions between electrical stimulation and the dynamics of spinal circuits.
Surgical Neuroanatomy Lab
The Surgical Neuroanatomy Lab (SNL), under the direction of Paul Gardner, MD, has a dual educational and research role aiming to improve surgical techniques and outcomes by mastering knowledge of relevant surgical neuroanatomy.
Translational Neuro Oncology Lab
The Laboratory for Translational Neuro Oncology, led by Kalil Abdullah, MD, develops novel preclinical models of glioma and identifies drug targets for early-phase clinical trials in patients with malignant brain tumors